Typical Anti-Psychotic Drugs
strong correlation for D2. High motor side effects. Alleviate positive symptoms.
Atypical Anti-Psychotic Drugs
less likely to cause EPS symptoms. Effective in treating positive and negative symptoms. Little/no effect on prolactin levels.
tri-cyclic anti-psychotics. Act via blockade of D2 receptors. lipophobic.
aliphatic. low potency. Side effects: sedation, EPS, weight gain, cardiotoxicity, lowering seizure threshold, photosensitivity.
high potency, EPS, hyperprolactinemia, weight gain. Used as depot injection.
EPS, tardive dyskinesia, high potency, lower sedation, autonomic side effects.
EPS, sedation, postural hypotension.
low potency, lowers seizure threshold, agranulocytosis.
Effective for negative symptoms, refractory schizophrenia, low doses have little effects.
used for bipolar, and major depressive disorder. Sedation.
Improves negative and positive symptoms. no EPS. Sedation, dizziness, weight gain.
D1/D2 antagonist. used for bipolar. Improves negative and positive symptoms. Sedation
slows down recovery rate of voltage gated Na+ channels. limits repetitive firing.
slows recovery rate of voltage gated Na+ channels. limits repetitive firing. calcium antagonist effect
slows recovery of voltage gated Na+ channels. limits repetitive firing. Inhibits GABA degrading enzymes.
slows recovery rate of voltage gated Na+ channels. limits repetitive firing. inhibits nt release. well tolerated in elderly. Causes Rash.
unknown mechanism. used usually for patients with generalized seizures.
Keto analogue of Carbamazepine.
increases GABA levels by inhibiting transport.
sustained repetitive Na+ channel firing. causes weight loss.
Adverse effects of Anti-epileptic drugs
ataxia, confusion, paraesthsias, weight loss, induction of CYP3A enzymes, RASH, hepatic failure.