Compare ESTROGEN receptor BETA and ALPHA.
-BETA is the INHIBING gene and...
-ALPHA is the ACTIVATING gene
-Estrogen beta- part of NEGative feedback inhibiting GnRH Production and Release.
-Estrogen alpha- contributes to NEGative feedback by INHIBITORY INPUT.
-ALSO, part of POSITIVE feedback because it also ACTIVATES PROGESTIN receptors.
What is the DIFFERENCE between ACTIVATIONAL and ORGANIZATIONAL EFFECTS of SEX HORMONES on SEXUAL BEHAVIOR?
-Organizational effects: active during DEVELOPMENT to modify structure or physiological function; relatively permanent changes. (ie. organizing your brain to think a certain way in coherence with appropriate gender)
-Activational: active LATER in life cycle to trigger or modulate behavior or seasonal expression of a trait; transient and REVERSIBLE EFFECTS.
**organizational effect (of testosterone) - sets the brain to react to activational effects (of testosterone) later on in life
Understand the role of testosterone, and sry gene in sexual dimorphism.
-Testosterone: MASCULINIZATION of the GENITAL and the BRAIN;
-Androgen, male sex hormone synthesized in the testes, responsible for SECONDARY male sex characteristics, produced from PROGESTERONE.
-Sry gene: located on the Y CHROMOSOME and CODES for producing TESTICLES,
-if Sry gene is NOT PRESENT, then the body produces OVARIES.