Chronic Leukemias
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9 terms
Terms | Definitions |
|---|---|
 CML- cytogenetics- | excess mature neutrophil production t(9;22) = Philadelphia chromosome - promotes fusion of 2 genes: BCR-ABL gene BCR-ABL gene codes for BCR-ABL TK (normally does not occur) - BCR-ABL TK actived = uncontrolled signal transduction hematologic, cytogenetic, molecular responses |
| CML - initial therapy - | imatinib dasatinib - MPE nilotinib - QT prolongation |
| CML - second line tx - | imatinib dose escalation dasatinib - higher doses (140 mg daily) in accelerated phase nilotinib - allo SCT |
| CML - blast crisis - | induction chemo &/or TKI then HSCT clinical trial |
| CLL | slow growing s/sx - anemia - lymphocytosis - thrombocytopenia - hypogammaglobinemia indolent Richter's transformation - tx'd w/ CHOP - secondary malignancy |
| CLL - first line tx - | fludarabine fludarabine + cyclophosphamide bendamustine FCR |
| CLL - second line | fludarabine alemtuzumab PCR (pentostatin, cyclophosphamide) OFAR (Oxaliplatin) alemtuzumab + R mini allo tx |
| CLL - relapse - | FCR > FC Ofatumumab (third line) |
| CLL - ofatumumab - | binds to small and large epitopes on CD20 antigen on B-cells (binds longer than rituximab) |
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