mimics structure of Ala-Ala. Binds to penicillin binding proteins (transpeptidases). Stimulates autolysins. Result is cell wall loses rigidity.
Beta lactamase inhibitors
Irreversibly inhibit beta lactamase, have no antibacterial activity alone.
Have 2 R groups for transpeptidase binding.
glycopeptide antibiotic, Stops formation of peptidoglycan chains that form bacterial cell wall, also damages cell membrane. No B ring.
Just a B ring, used in parenteral and inhalants. Often combined with amino glycosides. Inactivated by metal beta lactamases
Drug of choice for Serratia, Enterobacter, Citrobacter
Inhibits cell wall formation, different from other beta lactams. Interferes with transfer of peptidoglycan polymer units in cell wall.