Exam 2 Antipsychotics/Anti-ADHD

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Risperdal

risperidone

Atypical Antipsychoitc
bipolar mania, schizophrenia, autism

tablet
oral solution
ODT - Remeron M-Tab
once or BID

Invega

paliperidone

Atypical antipsychotic

active metabolite of risperidone

Zyprexa

olanzapine

Atypical Antipsychotic
bipolar disorder, schizophrenia
tablet
ODT - Zyprexa Zydis
once daily

Seroquel

quetiapine

Atypical Antipsychotic
bipolar disorder, schizophrenia, depression add-on
tablet
BID

Seroquel XR

quetiapine

Atypical Antipsychotic
bipolar disorder, schizophrenia, depression add-on
ER tablet
once daily

Abilify

aripiprazole

Atypical Antipsychotic
bipolar disorder, schizophrenia, autism, depression add on

tablet
oral solution
ODT - Abilify Discmelt
once daily

Geodon

zaprasidone

Atypical Antipsychotic
bipolar disorder, schizophrenia
capsule
BID

Ambien

zolpidem

Imidazopyridine Hypnotic
insomnia
5, 10 mg tablet
once daily

zolpidem my cause sleep-driving, cooking or phone calls

Ambien CR

zolpidem

Imidazopyridine Hypnotic
insomnia
6.25, 12.5 mg ER tablet
once daily
*5 or 10 mg immediate release with remainder released 3 hours later to maintain sleep*

Edluar

zolpidem

Imidazopyridine Hypnotic
insomnia
5,10 mg sublingual tablet
once daily

zolpidem my cause sleep-driving, cooking or phone calls

Sonata

zaleplon

Pyrazolopyrimidine Hypnotic
insomnia
5, 10 mg capsule
once daily

Lunesta

eszopiclone

Cyclopyrrolone Hypnotic
insomnia
1, 2, 3 mg tablet
once daily

adverse effect = unpleasant aftertaste

Rozerem

ramelteon

Melatonin Receptor Agonist Hypnotic
insomnia
8 mg tablet
once daily

disorder characterized by difficulty in sustaining attention, poor concentration, poor time management, and often hyperactivity

Attention Deficit/Hyperactivity Disorder (ADHD)

Ritalin, Methylin

methylphenidate

CNS Stimulant - CII
Treatment of ADHD and narcolepsy in patients > 6yrs
5, 10, 20 mg tablet
BID or TID

Adverse Reactions = insomnia and nervousness

Ritalin LA

methylphenidate

CNS Stimulant - CII
Treatment of ADHD and narcolepsy in patients > 6yrs
10, 20, 30, 40 mg ER capsule (50% IR beads, 50% DR beads)
once daily
IR beads released immediately and DR beads released 4 hours later

Concerta

methylphenidate

CNS Stimulant - CII
Treatment of ADHD and narcolepsy in patients > 6yrs
18, 27, 36, 54 mg ER tablet
once daily

*outer drug overcoat surrounding an osmotic core
drug overcoat dissolves within one hour for initial dose, then released in controlled rate from osmotic core*

*empty tablet shell may appear in stool*

Metadate CD

methylphenidate

CNS Stimulant - CII
Treatment of ADHD and narcolepsy in patients > 6yrs

10, 20, 30, 40, 50, 60 mg ER capsule
once daily
IR and ER beads - 30% released immediately and 70% released more slowly

Daytrana

methylphenidate

CNS Stimulant - CII
Treatment of ADHD and narcolepsy in patients > 6yrs

10, 15, 20, 30 mg transdermal
apply to hip 2 hours before effect needed
remove after 9 hours
new system applied each morning

Focalin

dexmethylphenidate

CNS Stimulant - CII
ADHD
dextro isomer = active isomer of methylphenidate

2.5, 5, 10 mg tablets
BID

patients switching from methylphenidate to dexmethylphenidate should:

start with half their methylphenidate dose and titrate up

Focalin XR

dexmethylphenidate

CNS Stimulant - CII
ADHD
dextro isomer = active isomer of methylphenidate

5, 10, 15, 20, 30 mg ER capsules
once daily

30 minute onset of action for ADHD

detroamphetamime bound to lysine

pro-drug cleaved by GI enzymes

lisdexamfetamine

Vyvanse

lisdexamfetamine

CNS Stimulant - CII
ADHD

20, 30, 40, 50, 60, 70 mg capsules
once daily

Strattera

atomoxetine

Selective Norepinephrine Reuptake Inhibitor
not controlled
ADHD

10, 18, 25, 40, 60, 80, 100 mg capsules
once or BID

mechanism of action of atomoxetine

increases the availability of norepinephrine by blocking norepinephrine reuptake

hormone essential in regulating attention, impulse control and organization

norepinephrine

Intuniv

guanfacine

Not controlled
ADHD
1, 2, 3, 4 mg ER tablet
once daily

start with 1 mg dose and adjust in increments of 1mg/week
Adverse effects = bradycardia, hypotension, and syncope

Tenex

guanfacine

hypertension
tablet

Kapvay

clonidine

non-controlled
ADHD
0.1, 0.2 mg ER tablets
once daily

start with 0.1 mg dose and adjust in increments of 0.1 mg /week

Adverse effect = hypotension

Adderall

amphetamine, dextroamphetamine combo

CNS Stimulant - CII
ADHD and narcolepsy
5, 7.5, 10, 12.5, 15, 20, 30, mg tablet
once or BID

Adderall XR

amphetamine, dextroamphetamine combo

CNS Stimulant - CII
ADHD and narcolepsy
5, 10, 15, 20, 25, 30 mg ER capsule
once daily

Provigil

modafinil

CNS Stimulant - CIV
narcolepsy, shift work sleep disorder (SWSD)
100, 200 mg tablet
once daily

Nuvigil

armodafinil

CNS Stimulant - CIV
narcolepsy, shiftwork sleep disorder (SWSD)
R-isomer of modafinil
50, 150, 250 mg tablets
once daily

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