6 beta oxidation
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20 terms
Terms | Definitions |
|---|---|
 What effect does inceasing dbl bonds and dec c# have on MP of a F.A. | decreases m.p. |
| what is the omega f.a? | linoleate |
| what is carnitine found in? | meat |
| name the enzymes and whats happening in beta oxidation | acyl-CoA dehydrogenase puts down a dbl bond and gives you FADH2 enoyl-Coa hydratase adds OH to beta beta hydroxy acyl coa dehydrogenase makes a ketone to give NADH thiolase cuts with CoA-SH to make acetyl CoA + long chain F.A. |
| what other rxns are very similar to beta ox? | TCA starting from the enzyme that gives us FADH2 |
| if you have a 16 Carbon fa, how do we calculate the # of acetyl CoA and Fadh and nadh? | divide by two to get the acetyl coa divide by 2 minus one for the # of fadh2 and nadh |
| how many ATP per acetyl CoA? | 12 atp 1 atp + 3 Nadh(9atp) + 1 fadh2(2ATP) |
| however, in leading up to beta ox, we consumed some ATP. Where and how many? | to create fatty acyl coa 2 atp |
| What are we lacking when we have methylmalonyl acidosis? | B12 (bc the enzyme that uses this cofactor is named methylmalonyl coa mutase) |
| how many acyl coa dehydrogenase enzymes are there? Why? | 4, for various length F.A. |
| whats the name of the acyl coa DH enz that works on medium chain F.A.? | MCAD medium chain fatty acyl-coa dehydrogenase |
| what happens with a MCAD deficiency? | hypoglycemia lactic acidosis dicarboxylic aciduria |
| where does omega FA oxidation occur? | ER and MITO |
| whats the product of omega oxidation? | dicarboxylic acid(their production is accelerated by MCAD) |
| what FA is broken in alpha FA oxidation? | phytanic acid |
| where is phytanic acid produced? | chlorphyl breakdown product by plants! this is the most abundant plant FA vegetarians do a lot of this |
| what are the products of alpha oxidation? | co2, propionyl-coa, acetly coa |
| Name the disease when you have a defect in alpha oxidation pathway | Refsums disease, a neurological disease |
| what organelle can we do beta oxidation of very long chain FA in? | peroxisomes |
| Name of disease when theres a defect in the peroxisomal FA oxidation pathway? | Zellweger syndrome, a neurological disease |
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