What are the 2 ways to regenerate NADH?
what is the 1st e- carrier in ETC?
what are the e- carriers in the ETC?
2. Fe-S centers
3. Heme cytochromes
how many ketones does coenzyme Q have?
what is porphyria?
a defect in cytochrome. Make you turn brown in sunlight
what is the e- path in complex 1?
what is the e- path in complex 2?
FADH2-->succinate dehydrogenase--> Fe-S--> Q
What is the e- path in complex 3?
QH2 from complex 1 & 2 --> complex 3 --> cytochrome b--> cytochrome C1 -->Cytochrome c
What is the e- path in complex 4?
Cyt c--> VI -->cyt a--> cyt a3 --> O2=H20
what is the nerst equation?
∆G = -nF∆E
What affect does the proton gradient have on the complexes and electron flow?
inhibits the complexes
what is electron flow coupled to?
What activates ATP Synthase?
what inhibits ATP Synthase?
what inhibits Complex I? what other fxns do they have?
what inhibits Complex III? what other fxns do they have?
what inhibits Complex IV? what other fxns do they have?
What is DNP?
Dinitrophenol - an uncoupler
e- run thru but no ATP made
collapses H gradient, but keeps e- moving
what enzymes prevent ROS
where in the mitochondria is the H+ gradient accumulated?
which way does the head of ATP Synthase point?
what is the efficiencey of the ETC?
42 % of the energy found in NADH's e- are used to make ATP