Repress NFkB, Cox2 and inflam. cytokines
How do Glucocorticoids act on the body?
Not a long term treatment, used for flare ups or as a bridge
How are Glucocorticoids prescribed safely?
What are potential side effects of Glucocorticoids?
The frontline DMARD of choice for rheumatoid arthrits
Dihydrofolate Reductase, Thymidylate synthase
What enzymes do MTX/MTX-glu block?
MTX is a prodrug, must be polyglutamated over 25-30 weeks
Why is methotrexate such a slow actin drug?
3-10 pills, each w/ 2.5 mg. ~7mg per week.
What is the oral dosing of MTX?
80-90% cleared by the kidneys
How/how much is MTX cleared?
Hepatotoxicity, Pulmonary damage, Myelosuppression
What are potential toxicities of MTX?
Folic acid/folinic acid
What can pts take to prevent hematological side effects with MTX?
Etanercept, Infliximab, Adalimumab
What biological drugs targets TNFa to treat RA?