5 Written Questions

1. with slow acetylators, chance of SLE; need to remove drug
2. TB; meningococcal carriers
3. cell wall synthesis inhibitor; used to tx TB
4. blocks 50S; blocks peptidyl transferase
5. first line - most effective, lowest toxicity;

5 Matching Questions

1. sulfonamides
2. sulfonamides MOA
3. sulfonamides indications
4. isoniazid, INH - MOR
5. aminoglycosides MOR

1. a broad spectrum; gram + and gram -
2. b de novo synthesis of nucelotides need PABA; inhibit the actino of dihydropteroate synthase so block synthesis of dihydrofolate
3. c adenylating, acetylation or phosphorylation of aminoglycosides
4. d para-aminobenzoic acid (PABA)
5. e mutated decrease in uptake of INH; **mutations of katG gene resulting in loss of catalase-peroxidase enzyme required for INH activation; b/c of resistance = can need tx for 2 yrs

5 Multiple Choice Questions

1. PO; wide distribution* b/c TB can get into tissues even to caseous lesions; good distribution to CNS; metabolized by hepatic acetyltransferase - rapid/slow acetylators (30%=slow, can lead to toxicity of drug); most excreted as acetylated metabolite
   1. INH adverse rxns
   2. INH dosing/use
   3. INH pharmacokinetics
   4. pyrazinamide
2. increased drug transport out of bacteria (efflux); mutations in the 50S that decrease binding of drug
   1. macrolides resistance
   2. macrolides adverse/contra
   3. metronidazole MOR
   4. bacitracin
3. 4th generation; VERY broad; don't use; gram + coverage of 1st gen and gram - coverage of 3rd
   1. cefepime
   2. meropenem
   3. cefoxitin
   4. cerfuroxime
4. bacterial gain efflux pumps by conjugation
   1. tetracyclines
   2. tetracylcines MOR
   3. cefazolin
   4. penicillins
5. 1st generation; effective against gram +!!; don't cross BBB
   1. cefazolin
   2. cephalexin
   3. cephalosporins
   4. ciprofloxin

5 True/False Questions

1. linezolid MOA → bind to P site on 50S; for Gram +

   True        False

2. nafcillin → antistaphyloccal; tx serious b-lactamase staph; for MSSA

   True        False

3. gram - cell wall → outer membrane of lipopolysaccharide; harder to get into this cell

   True        False

4. quinolones and fluroquinolones MOR → mutate target, efflus or don't let it in

   True        False

5. M. tuberculosis → tuberculosis; 3% of the population infected; transmission = overcrowding, poor personal and public hygiene; * respiratory route; primary (caseous lesions) and secondary infection (reactivation)

   True        False