Chapter 5 Methods and Strategies
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19 terms
Terms | Definitions |
|---|---|
Brain function vs behavior | circuits within the brain perform functions, not behaviors |
excitotoxic lesion | a brain lesion produced by intracerebral ijection of an excitatory amino acid, such as kainic acid |
sham lesion | a placebo procedure that duplicates all the steps of producing a brain legion except for the one that actually causes brain damage |
fixative | a chemical such as formalin; used to prepare a and preserve body tissue |
formalin | the aqueous solution of formaldehde gas; most commonly used fixative |
microtome | an instrument that produces very thin slices of body tissue |
MRI | magnetic resonance imaging |
fMRI | functional MRI, measures signal changes in the brain due to chanign neural activity |
DTI | diffusion tensor imaging- white matter connectivity of the brain |
CT | computed tomography |
PET | positron emission tomogrpahy |
SPECT | single photo emission computed tomogrpahy-type of nuclear imaging test that shows how blood flows to tissues and organs |
EEG | electroencephaogram |
magnetoencephalography | procedure that detects groups of synchrounsuly activated neurons by means of the magnetic field induced by their electrical activity.uses SQUIDS |
FOS | a protien produced in the nucleus of a neuron in response to synaptic stimulation |
Transcranial magnetic stimulation (TMS) | stimulation of the cerebral cortex by means of magnetic fields produced by passing pulses or electricity through a coil of wire placed next to the skull; interferes with the functions of the brain region that is stimulted |
Recording metabolic and synaptic activity | Functional imaging- a computerized method of detecting metabolic or chemical changes in particular regions o the brainPET - use a device that reveals the locailzation of a radioactive tracer in a living brain |
Targeted Mutations | recently developed-mutated genes produced in the laboratory and inserted into the chromosomes of mice (knockout genes) -these mutate genes are defective: they fail to produce a functional protien |
antisense oligonucleotides | a modified strand of RNA or DNA that binds with a specific molecule of messenger RNA and prevents it from producing its particular protein |
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