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5 Written Questions

5 Matching Questions

  1. Platelet activating factor effects
  2. Complement disorders
  3. Drug toxicity
  4. Drug allergy: VAs
  5. Disorders of immunoglobulins
  1. a Release of vasoactive amines
  2. b Manifestations dependent upon drug
    Fairly predictable
    No prior exposure needed
    Dose related
    Onset may be delayed
  3. c Deficiencies:
    X-linked agammaglobulinemia
    Acquired hypoimmunoglobulinemia
    Selective immunoglobulin A deficiency
    Cold autoimmune diseases
    Multiple myeloma
    Waldenstrom's macroglobulinemia
  4. d Hereditary angioedema
  5. e Halothane hepatitis- trifluoroacetyl halide metabolites + hepatic microsomal proteins->neoantigens
    Sevo doesn't produce oxidative halide metabolites

5 Multiple Choice Questions

  1. Vanco‐ life threatening anaphylactic &
    anaphylactoid (red man syndrome) reactions
    PCN‐ most common cause of fatal anaphylaxis (structurally r/t cephalosporins-> theoretical ↑d risk of allergy
  2. Rare, accounts for 1% of adverse reactions to locals
    Ester based->PABA
    Preservatives (methylparaben, propylparaben) similar to PABA
    No proven cross-reactivity between ester & amides
  3. Cold agglutinins->activation of compliment & plts, hyper‐viscosity, renal failure
  4. Airway‐ macroglossia
    CV‐ conduction disturbance, RHF
    Renal‐ nephrotic syndrome
    Nerves‐ autonomic neuropathy, nerve compression
  5. Antigens are normally endogenous, although exogenous chemicals (haptens) which can attach to cell membranes
    Drug-induced hemolytic anemia, granulocytopenia & thrombocytopenia
    IgM & IgG mediated
    Phagocytes & K cells play a role

5 True/False Questions

  1. Anaphylaxis primary exposureSensitization via antigen specific IgE antibodies


  2. Dosing for epinephrine for shock but w/ pressure0.01 mg - 0.1 mg IV. Do not give 1 mg!


  3. X‐linked agammaglobulinemia‐Cold agglutinins->activation of compliment & plts, hyper‐viscosity, renal failure


  4. IgA‐Secretions, topical defense


  5. Cold autoimmune diseasesIgM binds erythrocytes when cold->hemolysis, compliment activation, acrocyanosis, Raynaud's, purpura, gangrene, nephritis


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