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5 Written Questions

5 Matching Questions

  1. Drug allergy: VAs
  2. S/S of anaphylactoid reactions
  3. Histamine effects
  4. Drug allergy: crossmatched blood
  5. X‐linked agammaglobulinemia‐
  1. a Capillary permeability
  2. b Degranulations & release of vasoactive mediators->hypotension & CV collapse
  3. c Inability to form any class of antibodies (absent mature B‐lymphocytes)->recurrent bacterial infections
  4. d 3% incidence of allergic reactionst
  5. e Halothane hepatitis- trifluoroacetyl halide metabolites + hepatic microsomal proteins->neoantigens
    Sevo doesn't produce oxidative halide metabolites

5 Multiple Choice Questions

  1. IgM binds erythrocytes when cold->hemolysis, compliment activation, acrocyanosis, Raynaud's, purpura, gangrene, nephritis
  2. Rare, accounts for 1% of adverse reactions to locals
    Ester based->PABA
    Preservatives (methylparaben, propylparaben) similar to PABA
    No proven cross-reactivity between ester & amides
  3. 1 mg IV
  4. Rare
    MSO4->histamine release->possible anaphylactoid reaction
  5. Account for 60% of periop drug induced allergic reactions
    High incidence (50%) of cross sensitivity
    Quaternary ammonium groups (nondepolarizers)

5 True/False Questions

  1. Drug allergy: abxVanco‐ life threatening anaphylactic &
    anaphylactoid (red man syndrome) reactions
    PCN‐ most common cause of fatal anaphylaxis (structurally r/t cephalosporins-> theoretical ↑d risk of allergy


  2. Dosing for epinephrine1 mg 1:1000
    0.01 mg/kg IM
    Max 0.5 mg in adult
    Max 0.3 mg in child


  3. Anaphylactoid reactionsNot IgE mediated, similar clinical presentation, don't need prior sensitization


  4. Allergic reactionsAnaphylaxis‐ IgE mediated reaction
    Rhinitis‐ IgE mediated
    Food & drug allergies


  5. Drug allergy: Induction drugsBarbs‐ rare, severe
    Propofol- egg lecithin emulsion, most common, high incidence of bronchospasm


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