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5 Written questions

5 Matching questions

  1. Drug allergy: Opioids
  2. Vasoactive mediators
  3. Drug allergy: abx
  4. Hereditary angioedema
  5. Disorders of immunoglobulins
  1. a Histamine, leukotrienes, prostaglandins, eosinophil & neutrophil chemotactic factor, plt activating factor
  2. b Airway emergency
    C1 esterase inhibitor->poorly regulated compliment activation->release of vasoactive mediators (bradykinin)->episodic airway edema
  3. c Rare
    MSO4->histamine release->possible anaphylactoid reaction
  4. d Deficiencies:
    X-linked agammaglobulinemia
    Acquired hypoimmunoglobulinemia
    Selective immunoglobulin A deficiency
    Cold autoimmune diseases
    Multiple myeloma
    Waldenstrom's macroglobulinemia
  5. e Vanco‐ life threatening anaphylactic &
    anaphylactoid (red man syndrome) reactions
    PCN‐ most common cause of fatal anaphylaxis (structurally r/t cephalosporins-> theoretical ↑d risk of allergy

5 Multiple choice questions

  1. Antigens are normally endogenous, although exogenous chemicals (haptens) which can attach to cell membranes
    Drug-induced hemolytic anemia, granulocytopenia & thrombocytopenia
    IgM & IgG mediated
    Phagocytes & K cells play a role
  2. Capillary permeability
  3. Halothane hepatitis- trifluoroacetyl halide metabolites + hepatic microsomal proteins->neoantigens
    Sevo doesn't produce oxidative halide metabolites
  4. O2, IV fluids, epinephrine, H1 antagonists, steroids
  5. Capillary permeability
    Negative inotropy
    Coronary artery vasoconstriction

5 True/False questions

  1. Anaphylaxis primary exposureSensitization via antigen specific IgE antibodies


  2. IgE‐Mast cells, Anaphylaxis and allergy


  3. Anaphylaxis secondary exposureNot IgE mediated, similar clinical presentation, don't need prior sensitization


  4. IgM‐Secretions, topical defense


  5. Drug toxicityManifestations dependent upon drug
    Fairly predictable
    No prior exposure needed
    Dose related
    Onset may be delayed


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