5 Written questions
5 Matching questions
- Gap Junctions
- end plate potential (EPP)
- small clear-core vesicle
- a membrane potential on an end plate large enough to trigger an action potential
- b reversibly binds to synaptic vesicles and may cross link vesicle to actin filaments in the cytoskeleton to keep the vesicles tethered within the reserve pool.
- c Make electrical synapses possible. Consists of hexameric subunits made up of subunits called connexons.
- d Vesicles that contain small molecule neurotransmitters. These vesicles appear clear in electron micrographs. Made in the axon terminal by enzymes shipped down by slow axonal transport from the soma.
- e a protein that causes the final pinching-off of the membrane that completes the production of coated vesicles in the synaptic vesicle cycle.
5 Multiple choice questions
- Involved in priming synaptic vesicles for release. Work by regulating the assembly of SNARE proteins.
- make up EPPS and correspond to the release of just one or two vesicle. Small, happen spontaneously, and cannot trigger an AP.
- an ATPase involved in priming synaptic vesicle for fusion
- a SNARE protein on the surface of the synaptic vesicle. Binds Ca++ at concentrations similar to those required to trigger vesicle fusion, basically allowing it to act as a Ca++ sensor and triggering fusion.
- partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.
5 True/False questions
large dense-core vesicles → Vesicles that contain small molecule neurotransmitters. These vesicles appear clear in electron micrographs. Made in the axon terminal by enzymes shipped down by slow axonal transport from the soma.
Neurotransmitters → chemical agents acting as messengers between the communicating neurons. Released from vesicle when the is a large Ca++ influx into the cell. How many are released depends on how much Ca++ enters the terminal.
clathrin → a kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool
end plates → neuromuscular junctions when synapses from the pre-synaptic axon elaborate and appear in a saucer-like shape on the muscle fiber
syntaxin and SNAP-25 → T-SNARE proteins embedded to the pre-synapatic membrane; attach to synaptic vesicles for vesicle fusion