5 Written questions
5 Matching questions
- end plate potential (EPP)
- synaptic vesicle cycle
- end plates
- a membrane potential on an end plate large enough to trigger an action potential
- b neuromuscular junctions when synapses from the pre-synaptic axon elaborate and appear in a saucer-like shape on the muscle fiber
- c How neurotransmitters are referred to when two or more of them are present in the same nerve terminal.
- d a SNARE protein on the surface of the synaptic vesicle. Binds Ca++ at concentrations similar to those required to trigger vesicle fusion, basically allowing it to act as a Ca++ sensor and triggering fusion.
- e recycling process for synaptic vesicle. Process takes about 1 minute.
5 Multiple choice questions
- make up EPPS and correspond to the release of just one or two vesicle. Small, happen spontaneously, and cannot trigger an AP.
- Make electrical synapses possible. Consists of hexameric subunits made up of subunits called connexons.
- reversibly binds to synaptic vesicles and may cross link vesicle to actin filaments in the cytoskeleton to keep the vesicles tethered within the reserve pool.
- Package neuropeptides. These vesicles are much larger in size than small clear-core vesicles. Made in the soma and shipped down to the terminal via fast axonal transport.
- partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.
5 True/False questions
CamKII → a kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool
SNAPs (soluble NSF-attachments proteins) → an ATPase involved in priming synaptic vesicle for fusion
hsc-70 → with the aid of auxilin, this removes the clathrin coating so that the vesicle can move onto other phases of recycling
Neurotransmitters → chemical agents acting as messengers between the communicating neurons. Released from vesicle when the is a large Ca++ influx into the cell. How many are released depends on how much Ca++ enters the terminal.
syntaxin and SNAP-25 → Work by allowing ionic current to flow PASSIVELY through the gap junction pores from one neuron to the next. Very fast transmission.