5 Written Questions
5 Matching Questions
- synaptic vesicle cycle
- acetylcholine (ACh)
- syntaxin and SNAP-25
- SNAPs (soluble NSF-attachments proteins)
- Electrical synapses
- a recycling process for synaptic vesicle. Process takes about 1 minute.
- b Work by allowing ionic current to flow PASSIVELY through the gap junction pores from one neuron to the next. Very fast transmission.
- c Involved in priming synaptic vesicles for release. Work by regulating the assembly of SNARE proteins.
- d A neurotransmitter found primarily at neuromuscular junctions of the striated muscles and in the visceral motor system. Involved in muscle contraction and heart rate increases.
- e T-SNARE proteins embedded to the pre-synapatic membrane; attach to synaptic vesicles for vesicle fusion
5 Multiple Choice Questions
- a kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool
- partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.
- a protein that causes the final pinching-off of the membrane that completes the production of coated vesicles in the synaptic vesicle cycle.
- Make electrical synapses possible. Consists of hexameric subunits made up of subunits called connexons.
- neuromuscular junctions when synapses from the pre-synaptic axon elaborate and appear in a saucer-like shape on the muscle fiber
5 True/False Questions
synaptotagmin → a SNARE protein on the surface of the synaptic vesicle. Binds Ca++ at concentrations similar to those required to trigger vesicle fusion, basically allowing it to act as a Ca++ sensor and triggering fusion.
clathrin → a very important protein involved in endocyctotic budding of vesicles from the plasma membrane. Assemble together (by polymerization) to form membrane coats during the budding of the phase synaptic vesicle cycle.
hsc-70 → with the aid of auxilin, this removes the clathrin coating so that the vesicle can move onto other phases of recycling
large dense-core vesicles → Vesicles that contain small molecule neurotransmitters. These vesicles appear clear in electron micrographs. Made in the axon terminal by enzymes shipped down by slow axonal transport from the soma.
co-transmitters → How neurotransmitters are referred to when two or more of them are present in the same nerve terminal.