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5 Written Questions

5 Matching Questions

  1. NSF (NEM-sensitive fusion protein)
  2. SNAPs (soluble NSF-attachments proteins)
  3. curare
  4. mini end plate potentials (MEPPS)
  5. co-transmitters
  1. a How neurotransmitters are referred to when two or more of them are present in the same nerve terminal.
  2. b Involved in priming synaptic vesicles for release. Work by regulating the assembly of SNARE proteins.
  3. c an ATPase involved in priming synaptic vesicle for fusion
  4. d make up EPPS and correspond to the release of just one or two vesicle. Small, happen spontaneously, and cannot trigger an AP.
  5. e partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.

5 Multiple Choice Questions

  1. Package neuropeptides. These vesicles are much larger in size than small clear-core vesicles. Made in the soma and shipped down to the terminal via fast axonal transport.
  2. reversibly binds to synaptic vesicles and may cross link vesicle to actin filaments in the cytoskeleton to keep the vesicles tethered within the reserve pool.
  3. membrane potential on an end plate large enough to trigger an action potential
  4. T-SNARE proteins embedded to the pre-synapatic membrane; attach to synaptic vesicles for vesicle fusion
  5. Work by allowing ionic current to flow PASSIVELY through the gap junction pores from one neuron to the next. Very fast transmission.

5 True/False Questions

  1. hsc-70partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.


  2. clathrina kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool


  3. synaptotagmina SNARE protein on the surface of the synaptic vesicle. Binds Ca++ at concentrations similar to those required to trigger vesicle fusion, basically allowing it to act as a Ca++ sensor and triggering fusion.


  4. synaptic vesicle cyclerecycling process for synaptic vesicle. Process takes about 1 minute.


  5. Neurotransmitterschemical agents acting as messengers between the communicating neurons. Released from vesicle when the is a large Ca++ influx into the cell. How many are released depends on how much Ca++ enters the terminal.


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