5 Written Questions
5 Matching Questions
- end plates
- acetylcholine (ACh)
- mini end plate potentials (MEPPS)
- Gap Junctions
- a neuromuscular junctions when synapses from the pre-synaptic axon elaborate and appear in a saucer-like shape on the muscle fiber
- b make up EPPS and correspond to the release of just one or two vesicle. Small, happen spontaneously, and cannot trigger an AP.
- c partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.
- d Make electrical synapses possible. Consists of hexameric subunits made up of subunits called connexons.
- e A neurotransmitter found primarily at neuromuscular junctions of the striated muscles and in the visceral motor system. Involved in muscle contraction and heart rate increases.
5 Multiple Choice Questions
- chemical agents acting as messengers between the communicating neurons. Released from vesicle when the is a large Ca++ influx into the cell. How many are released depends on how much Ca++ enters the terminal.
- with the aid of auxilin, this removes the clathrin coating so that the vesicle can move onto other phases of recycling
- a SNARE protein on the surface of the synaptic vesicle. Binds Ca++ at concentrations similar to those required to trigger vesicle fusion, basically allowing it to act as a Ca++ sensor and triggering fusion.
- Work by allowing ionic current to flow PASSIVELY through the gap junction pores from one neuron to the next. Very fast transmission.
- an ATPase involved in priming synaptic vesicle for fusion
5 True/False Questions
synaptobrevin → a V-SNARE protein that binds to the synaptic vesicle before exocytosis
clathrin → a very important protein involved in endocyctotic budding of vesicles from the plasma membrane. Assemble together (by polymerization) to form membrane coats during the budding of the phase synaptic vesicle cycle.
end plate potential (EPP) → membrane potential on an end plate large enough to trigger an action potential
CamKII → a kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool
dynamin → a protein that causes the final pinching-off of the membrane that completes the production of coated vesicles in the synaptic vesicle cycle.