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5 Written Questions

5 Matching Questions

  1. end plate potential (EPP)
  2. Gap Junctions
  3. synaptic vesicle cycle
  4. end plates
  5. synaptotagmin
  1. a Make electrical synapses possible. Consists of hexameric subunits made up of subunits called connexons.
  2. b recycling process for synaptic vesicle. Process takes about 1 minute.
  3. c neuromuscular junctions when synapses from the pre-synaptic axon elaborate and appear in a saucer-like shape on the muscle fiber
  4. d membrane potential on an end plate large enough to trigger an action potential
  5. e a SNARE protein on the surface of the synaptic vesicle. Binds Ca++ at concentrations similar to those required to trigger vesicle fusion, basically allowing it to act as a Ca++ sensor and triggering fusion.

5 Multiple Choice Questions

  1. Vesicles that contain small molecule neurotransmitters. These vesicles appear clear in electron micrographs. Made in the axon terminal by enzymes shipped down by slow axonal transport from the soma.
  2. make up EPPS and correspond to the release of just one or two vesicle. Small, happen spontaneously, and cannot trigger an AP.
  3. a kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool
  4. with the aid of auxilin, this removes the clathrin coating so that the vesicle can move onto other phases of recycling
  5. chemical agents acting as messengers between the communicating neurons. Released from vesicle when the is a large Ca++ influx into the cell. How many are released depends on how much Ca++ enters the terminal.

5 True/False Questions

  1. large dense-core vesiclesVesicles that contain small molecule neurotransmitters. These vesicles appear clear in electron micrographs. Made in the axon terminal by enzymes shipped down by slow axonal transport from the soma.

          

  2. Electrical synapsesreversibly binds to synaptic vesicles and may cross link vesicle to actin filaments in the cytoskeleton to keep the vesicles tethered within the reserve pool.

          

  3. clathrina kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool

          

  4. SNAPs (soluble NSF-attachments proteins)Involved in priming synaptic vesicles for release. Work by regulating the assembly of SNARE proteins.

          

  5. NSF (NEM-sensitive fusion protein)an ATPase involved in priming synaptic vesicle for fusion

          

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