5 Written Questions
5 Matching Questions
- NSF (NEM-sensitive fusion protein)
- SNAPs (soluble NSF-attachments proteins)
- mini end plate potentials (MEPPS)
- a How neurotransmitters are referred to when two or more of them are present in the same nerve terminal.
- b Involved in priming synaptic vesicles for release. Work by regulating the assembly of SNARE proteins.
- c an ATPase involved in priming synaptic vesicle for fusion
- d make up EPPS and correspond to the release of just one or two vesicle. Small, happen spontaneously, and cannot trigger an AP.
- e partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.
5 Multiple Choice Questions
- Package neuropeptides. These vesicles are much larger in size than small clear-core vesicles. Made in the soma and shipped down to the terminal via fast axonal transport.
- reversibly binds to synaptic vesicles and may cross link vesicle to actin filaments in the cytoskeleton to keep the vesicles tethered within the reserve pool.
- membrane potential on an end plate large enough to trigger an action potential
- T-SNARE proteins embedded to the pre-synapatic membrane; attach to synaptic vesicles for vesicle fusion
- Work by allowing ionic current to flow PASSIVELY through the gap junction pores from one neuron to the next. Very fast transmission.
5 True/False Questions
hsc-70 → partially blocks post synaptic ACh receptors when placed in the extracellular medium. Used to study EPPs and MEPPs.
clathrin → a kinase that phosphorylates synapsin and causes it to let go of the synaptic vesicles it is holding in the reserve pool
synaptotagmin → a SNARE protein on the surface of the synaptic vesicle. Binds Ca++ at concentrations similar to those required to trigger vesicle fusion, basically allowing it to act as a Ca++ sensor and triggering fusion.
synaptic vesicle cycle → recycling process for synaptic vesicle. Process takes about 1 minute.
Neurotransmitters → chemical agents acting as messengers between the communicating neurons. Released from vesicle when the is a large Ca++ influx into the cell. How many are released depends on how much Ca++ enters the terminal.