Set: CH 1: Five Major Types of Transmembrane Receptors with Enzymatic Cytosolic Domains

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With group: UCB Molecular Pharmacology X410
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All 6 terms

TermDefinition
Dimerize, Transphosphorylate, TyrosineRECEPTOR TYROSINE KINASES comprise the largest group of transmembrane receptors with enzymatic cytosolic domains. After activation these receptors _____ and _____ tyrosine residues on the cytoplasmic tail of the receptor. This leads to recruitment and subsequent ______ phosphorylation of a number of cytosolic signaling molecules.
Phosphate, TyrosineRECEPTOR TYROSINE PHOSPHATASES remove _____ groups (after activation) from specific ____ residues in cytoplasmic proteins.
Cluster, Recruit, PhosphorylateTYROSINE KINASE-ASSOCIATED RECEPTORS: Upon ligand activation, these receptors _____ together, and then _____ and activate cytosolic proteins known as "nonreceptor tyrosine kinases" which in turn _____ tyrosine residues of other proteins.
Dimerize, PhosphorylateRECEPTOR SERINE/THREONINE KINASES: (RSTKs) Upon ligand activation these receptors _____ , transphosphorylate, then ______ serine/threonine residues on cytosolic proteins.
GTP, cGMPRECEPTOR GUANYLYL CYCLASES: Ligand binding stimulates intrinsic receptor guanylyl cyclase activity, converting _____ to ____.
RTKs (Receptor Tyrosine Kinases), RTPs (Receptor Tyrosine Phosphatases), TKARs (Tyrosine Kinase-Associated Receptors), RSTKs (Receptor Serine/Threonine Kinases), RGCs (Receptor Guanyly Cyclases)Name the five major categories of transmembrane receptors with enzymatic cytosolic domains.

Set Information

Terms 6
Creator aaycinena
Created February 16, 2009
Group UCB Molecular Pharmacology X410
Subjects pharmacology, Receptors, enzymatic cytosolic domains
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Description

From "Principles of Pharmacology" 2nd ed. by Golan, pg.12-14

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  1. RTKs (Receptor Tyrosine Kinases), RTPs (Receptor Tyrosine Phosphatases), TKARs (Tyrosine Kinase-Associated Receptors), RSTKs (Receptor Serine/Threonine Kinases), RGCs (Receptor Guanyly Cyclases) Name the five major categories of transmembrane receptors with enzymatic cytosolic domains. - 7 misses
  2. GTP, cGMP RECEPTOR GUANYLYL CYCLASES: Ligand binding stimulates intrinsic receptor guanylyl cyclase activity, converting _____ to ____. - 4 misses
  3. Dimerize, Transphosphorylate, Tyrosine RECEPTOR TYROSINE KINASES comprise the largest group of transmembrane receptors with enzymatic cytosolic domains. After activation these receptors _____ and _____ tyrosine residues on the cytoplasmic tail of the receptor. This leads to recruitment and subsequent ______ phosphorylation of a number of cytosolic signaling molecules. - 3 misses
  4. Cluster, Recruit, Phosphorylate TYROSINE KINASE-ASSOCIATED RECEPTORS: Upon ligand activation, these receptors _____ together, and then _____ and activate cytosolic proteins known as "nonreceptor tyrosine kinases" which in turn _____ tyrosine residues of other proteins. - 3 misses
  5. Dimerize, Phosphorylate RECEPTOR SERINE/THREONINE KINASES: (RSTKs) Upon ligand activation these receptors _____ , transphosphorylate, then ______ serine/threonine residues on cytosolic proteins. - 1 miss