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loop diuretics inhibit sodium and water reabsorption in the loop of henle and increase potassium loss in the distal tubule. as a result promote sodium, chloride, potassium and water excretion thiazide diuretics promote excretion of sodium ,chloride, potassium, and water by decreasing their reabsorption in the distal tubule potassium-sparing diuretics promote excretion of sodium and water and by inhibiting sodium- potassium exchange in the distal tubule potassium sparing diuretics can be combination loop diuretics strongest thiazide diuretics most common