Ch 13 Viruses

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Tortora

Viruses

Filterable agents, only visible through electron microscope

Viruses

Obligatory intra-cellular parasites

virion

complete virus

composition

nucleic acid protected by protein coat, double or single stranded, capsid, spikes

classifications

phenotypic characteristics, such as morphology, nucleic acid type, mode of replication, host organisms, and the type of disease they cause

host range of virus

range of cell types a virus can attack

taxonomy

families by nucleic acid type, morphology,

grown

in living animal, embryonated egg, or cell cultures

cytopathic effects

effects of virus on cell

how multiplication occurs

attachment, penetration (endocytosis or fusion), uncoating (virus removes capsid), reproduction, maturation, release

retrovirus

RNA virus that contain retroviral RNA

prion

infectious protein that causes spongy-form encephalopathies (mad cow disease, Kreutz-felt Jachob disease, sheep scraping), caused by cellular prion protein to scrapy proteins

viroid

short pieces of enveloped RNA with no viral coat that infect plant cells

envelope

combination of protein, carbohydrate, and covering virus

provirus

viral DNA integrated into host's DNA

virus obtains an envelope

budding

RNA viruses multiply where

cytoplasm

DNA

reverse transcriptase virus DNA incorporated where

HIV

does not make other animals than humans sick

all viruses have

capsid

bacteriophage

virus that infects bacteria

Parvoviridae

cause fetal death, gastroenteritis, SINGLE STRAND DNA

DOUBLE STRAND DNA

HAPP: herpesviridae, adenoviridae, papoviridae, poxviridae

Herpesviridae

fever blisters, chickenpox, DOUBLE STRAND DNA

Adenoviridae

respiratory infections, DOUBLE STRAND DNA

Papovaviridae

cause tumors, warts, cancer, DOUBLE STRAND DNA

Poxviridae

smallpox, cowpox, DOUBLE STRAND DNA

sense STRAND RNA

PiT

Picornaviridae

polio, common cold, sense STRAND RNA

Togaviridae

arthropod transmitted viruses, sense STRAND RNA

Antisense strand RNA

PORF: paramyxoviridae, orthomyxoviridae, rhabdoviridae, filoviridae

Paramyxoviridae

cause mumps, antisense strand RNA

Orthomyxoviridae

Influenza, antisense strand RNA

Rhabdoviridae

rabies virus, antisense strand RNA

Filoviridae

helical viruses; ebola, antisense strand RNA

Retroviridae

HIV and tumor viruses, two strands of RNA

Reoviridae

mild respiratory infections, gastroenteritis, double strand RNA

viral multiplication

APUB MR., attachment, penetration, uncoating, biosynthesis, maturation, release

prion disease

Creutzfeldth-Jakob,

Distinguish cancer cells

Undergo mitosis more rapidly- drug therapy targets "rapidly growing" cells; Not controlled by "contact inhibition;" Undergo "dedifferentiation", revert back to a form of embryonic cells, tend to be less "round" in shape and have more chromosomal abnormalities

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