Advertisement Upgrade to remove ads

NSAIDs

Name the NSAIDS.

Aspirin
Ibuprofen
Indomethacin
Ketorolac
Naproxen
Piroxilam

What is a synthetic prostaglandin? What's the side affect?

Antidote for NSAID induced gastritis.
Misoprotol: causes diarrhea

Which compounds are used to treat pain?

Ibuprofen, Ketorolac
pneumonic (Keti)

Which compounds are used as an analgesic?

Aspirin, Indomethacin, Naproxen, Piroxialam
Pneumonic (PAIN)

Which drug is the same as naproxen but more costly?

Piroxialam

Analgesic which is better than aspirin?

Naproxen

Only NSAID given intraveneously?

Ketorolac

NSAID used to treat gout?

Indomethacin

What causes inflammation? edema and pain?

Cytokines and Prostaglandins released by PMNs

What is the precursor for ALL prostaglandins?

arachondic acid

What causes the release of arachodonic acid?

prostaglandins

What is the result of PGE2 release?

...

What is the enzyme of importance in the protaglandin biosynthesis pathway that controls the production of cyclic endoperoxides?

cyclo-oxygenase

Cyclic endoperoxides are converted into what three products?

Thromboxanes, Prostaglandins, and Prostacyclins

What is the purpose of thromboxanes?

aggregation of blood cells-clotting

What is the purpose of prostacyclin (PGI2)?

inhibits aggregation (vasodilator)

What is the affect of prostaglandins released in the stomach?

increased muscous secretion
reduced acid secretion
Inflammation in the immune system

What is the mode of action of an anti-inflammatory drug?

Block the cyclo-oxygenase

What is the affect of blocking the production of cyclic endoperoxides by inhibition of cyclo-oxygenase (COX)?

mucous secretion in the stomach decreases
acid secretion increases
results in gastritis
anti-inflammatory

Cyclo-oxygenase is 2 enzymes? what are adverse affect are they responsible for?

COX I enyzme inhibitor: gastritis
COX II enzyme inhibitor: stops inflammation

Number one weak acid? where is it absorbed?

aspirin: stomach

Three major affects of aspirin in the body?

inflammation, analgesia, anit-pyretic

What's the mode of action for aspirin?

it blocks the migration of PMNs into the tissue
blocks production arachidonic acid

How do steriod work? MOA?

block phospholipase A2 and stop arachidonic acid

How does aspirin work to reduce pain?

reduce PGE2 in the central nervous system

How does aspirin work as an antipyretic?

lowering PGE2 in the hypothalamus

What are the 2 reasons patients stop using aspirin?

gastritis and acidosis

What are the 2 molecules resulting from aspirin metabolism? What is the significance?

acetate (prevent plalet aggregation) and salicylate

Major use of aspirin?

DJD (degenerative joint disease) in the knee

What is a major difference between acetomenophen and aspirin?

acetomenophen is NOT an anti-inflammatory agent

What is a therapetic strategies for aspirin to avoid bleeding?

Given patient's aspirin products to relieve pain and disease; DVD; strategy is to keep a low dose by given it every OTHER day therapy (12 pills/day)

Antidote for NSAID over-dose?

misoprotol

How to avoid irritation of NSAID therapy?

add steroid with ketorolac

What is the reason that geriatic patients have adverse effects with acetomenophen?

They take it forever; benzoqueinone destroys the liver; glutathione (prodced in body) afterwards: acetylcysteine is the antidote since it has lots of SH groups

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions above and try again

Example:

Reload the page to try again!

Reload

Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

NEW! Voice Recording

Create Set