Describe enzyme activity of Citrate Synthase
Controlled by substrate availability
Inhibited by citrate and ATP (which increases the km of the enzyme for acetyl-SCoA)
Which enzyme releases the first CO2 in the CAC?
Five cofactors of Alpha ketoglutarate are
Alpha ketoglutarate is inhibited by
is Alpha ketoglutarate regulated by reverse phosphorylation?
Succinyl-SCoA synthetase drives the formation of ATP or GTP and in what level phosphorylation?
GTP in Substrate level Phosphorylation
Name an enzyme in the Kreb cycle that is an integral protein.
What is the cause of Leigh Syndrome?
Succinate dehydrogenase deficiency
What can lead to early encephalopathy and seizures?
Defective fumarase gene
It is inherited autosomal recessively