Citric Acid Cycle
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Created by:
bhochman on October 26, 2011
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9 terms
Terms | Definitions |
|---|---|
 Describe enzyme activity of Citrate Synthase | Controlled by substrate availability Inhibited by citrate and ATP (which increases the km of the enzyme for acetyl-SCoA) |
| Which enzyme releases the first CO2 in the CAC? | alpha ketoglutarate |
| Five cofactors of Alpha ketoglutarate are | -coenzyme A -thiamine pyrophosphate -NAD+ -FAD -lipoic acid |
| Alpha ketoglutarate is inhibited by | -Succinyl CoA -NADH -ATP |
| is Alpha ketoglutarate regulated by reverse phosphorylation? | Nope |
| Succinyl-SCoA synthetase drives the formation of ATP or GTP and in what level phosphorylation? | GTP in Substrate level Phosphorylation |
| Name an enzyme in the Kreb cycle that is an integral protein. | Succinate Dehydrogenase |
| What is the cause of Leigh Syndrome? | Succinate dehydrogenase deficiency |
| What can lead to early encephalopathy and seizures? | Defective fumarase gene It is inherited autosomal recessively |
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