Staphylococcus toxins and biologically active enzymes

Created by nakamur21 

Upgrade to
remove ads

6 terms · track 4, pathogens

Surface proteins clumping factor and firbrinonectin binding proteins

Clumping factor binds fibrinogen. Fibrinonectin binding proteins bind fibrinonectin. These playe key role in early infection

Protein A

Protein A binds the Fc portion of IgG, leaving the Ag binding site turned around, protein A contributes to the virulence as an antiphagocytic factor.

Coagulase

Most important determinant of S. aureus versus other staphylococci. Coagulase activates prothrombin without usual proteolytic cleavages to form a fibrin clot.

Alpha toxin

Alpha toxin inserts into host cell membranes to form pores. It lyses the membranes of host cels. Secreted by most S aureus strains, but not by coagulase negative cocci

Exfoliatin

Exfoliatin splits intraepidermal junctions.

Superantigen toxins

SAgs are secreted proteins that stimulate systemic effect after absorption from GI track or ingestion. These bind MHC II without processing and cause massive cytokine release.

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions above and try again

Example:

Reload the page to try again!

Reload

Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

NEW! Voice Recording

Click the mic to start.

Create Set