Staphylococcus toxins and biologically active enzymes
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6 terms
Terms | Definitions |
|---|---|
 Surface proteins clumping factor and firbrinonectin binding proteins | Clumping factor binds fibrinogen. Fibrinonectin binding proteins bind fibrinonectin. These playe key role in early infection |
| Protein A | Protein A binds the Fc portion of IgG, leaving the Ag binding site turned around, protein A contributes to the virulence as an antiphagocytic factor. |
| Coagulase | Most important determinant of S. aureus versus other staphylococci. Coagulase activates prothrombin without usual proteolytic cleavages to form a fibrin clot. |
| Alpha toxin | Alpha toxin inserts into host cell membranes to form pores. It lyses the membranes of host cels. Secreted by most S aureus strains, but not by coagulase negative cocci |
| Exfoliatin | Exfoliatin splits intraepidermal junctions. |
| Superantigen toxins | SAgs are secreted proteins that stimulate systemic effect after absorption from GI track or ingestion. These bind MHC II without processing and cause massive cytokine release. |
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