Anticancer drugs - antimetabolites
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Created by:
ctothebizza on November 1, 2011
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5 terms
Terms | Definitions |
|---|---|
 methotrexate | folic acid analog - inhibits DHF; choriocarcinoma, abortion; can induce myelosuppresion which can be reversed with leucovorin |
| 5 FU | pyrimidine analog - inhibits thymidylate synthase; treat OD with thymidine |
| 6 mercaptopurine | purine analog; metabolized by xanthine oxidase, so toxic with allopurinol |
| 6-thioguanine | pruine analog; safe with allopurinol |
| cytarabine | inhibit DNA polymerase |
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