What are 3 common features in feline liver disease clinical signs?
What are 3 major differences in the way cats handle bilirubin (compared to dogs)?
- Cats are deficient in glucoronyl transferase
- They rapidly become deficient in protein carriers and BR ligands if they aren't taking in protein
- They require taurine to conjugate their BA's
What are the top 3 reasons for jaundice in cats?
- Hepatic lipidosis
Why is bilirubinuria in a cat ALWAYS a cause for concern?
- it's never normal: no renal conjugation of bilirubin as in dogs
- cats have higher renal threshold (i.e., if you're seeing BR in the urine, there's a LOT of it in the system)
Why is elevated ALP in a cat ALWAYS a cause for concern?
- ALP has very short half-life in cats
- no corticosteroid induced ALP as in dogs (cALP)
Name 5 aspects of hepatic disease that are unique to cats, aside from bilirubinuria.
- Increased ALP always cause for concern
- GGT very sensitive indicator of liver disease & can be very high
- Hypoalbuminemia UNcommon
- Ascites UNcommon
- Prognosis better than in dogs
What serum biochemistry finding in hepatic lipidosis in cats is an exception to the typical changes they undergo with liver disease?
- Normal GGT
Name 3 extrahepatic conditions in cats associated with increased ALT.
- intestinal disease/IBD
True or false: a coagulation profile is less important in a cat with suspected liver disease than in a dog with suspected liver disease.
False. The opposite is true.
What pattern of chemistry values might guide you toward a diagnosis of cholangitis rather than lipidosis?
An ALT that is dramatically elevated and much MORE elevated than either GGT or ALP.
Which form of cholangitis in cats is associated with triaditis?
Compare and contrast neutrophilic and lymphocytic cholangitis in cats in terms of signalment, areas affected, and signs
Neutrophilic: older cats, involves bile ducts, cats very sick
Lymphocytic: younger cats, does NOT involve bile ducts, cats less sick
Which form of cholangitis in cats is associated more commonly with ascites?
How is lymphocytic cholangitis in cats treated?
What form of fat accumulates in the livers of cats with hepatic lipidosis?
Which form of hepatic lipidosis in cats is more common, primary or secondary?
Name 4 risk factors for hepatic lipidosis in cats.
- rapid weight loss
Describe the liver enzyme values in a cat with hepatic lipidosis.
- NORMAL GGT
- Dramatically elevated ALP
- ALT slightly increased
What are the 2 most important nutrients to give cats with hepatic lipidosis?