Antipsychotics
About this set
Created by:
emilyjem on November 7, 2011
Subjects:
pharmacology, neuropharmacology, USyd, PCOL3022
Description:
Lecture 20 of PCOL3022/PCOL3922 at the University of Sydney
Log in to favorite or report as inappropriate.
Order by
39 terms
Terms | Definitions |
|---|---|
 chlorpromazine | The first antipsychotic drug |
| haloperidol | A typical antipsychotic (belonging to the butyrophenones) |
| clozapine | The most efficacious, and the first atypical, antipsychotic drug |
| risperidone | An atypical antipsychotic (belonging to the benzisoxazols) |
| aripiprazole | An atypical antipsychotic (belonging to the quinolinones) |
| partial agonist | Unusually, aripiprazole is a ___ at D2 receptors |
| 80 | Percentage of D2 receptor occupancy at therapeutic doses for typical antipsychotics |
| 60 | Percentage of D2 receptor occupancy at therapeutic doses for atypical antipsychotics |
| dopamine D2 | Both typical and atypical antipsychotics are potent antagonists of this receptor |
| adrenoceptors | Both typical and atypical antipsychotics have a moderate affinity for alpha-... |
| 5-HT2 | Most atypical antipsychotics exhibit a high affinity for the ___ receptor |
| D4 | The superior efficacy of clozapine may be explained by its high affinity for the ___ receptor |
| D1 | Both typical and atypical antipsychotics have a moderate affinity for the dopamine ___ receptor |
| D3 | Atypical antipsychotics have a moderate affinity for the dopamine ___ receptor |
| motor, anticholinergic, endocrine | The three main types of side effects with typical antipsychotics |
| tardive dyskinesia | 20-40% of patients on typical antipsychotics develop this movement disorder |
| hyperprolactinaemia | One of the major endocrine side effects of typical antipsychotics |
| prolactin | Hyperprolactinaemia is the elevated secretion of ___ |
| epilepsy, cardiac problems | The two contraindications for both classes of antipsychotic |
| motor, endocrine | Atypical antipsychotics have greatly decreased ___ and ___ side effects |
| metabolic syndrome | A side effect of atypical antipsychotics that is not seen in typical antipsychotics |
| agranulocytosis | A serious haemotological side effect of clozapine |
| cardiomyopathy | A serious cardiac side effect of clozapine |
| greater compliance | The less serious side effects of atypical antipsychotics lead to... |
| treatment resistant | Atypical antipsychotics are more effective in ___ patients |
| benzamides | A class of atypical antipsychotics that does not exhibit high affinity for 5-HT2 receptors or moderate affinity for alpha-adrenoceptors |
| decreased endocrine | Unlike other atypical antipsychotics, risperidone does not have ___ side effects |
| H1, mACh | Antipsychotics also bind to the histamine ___ receptor and the ___ receptor |
| increased DA release | The short term effect of blocking D2 autoreceptors |
| decreased DA release | The long term effect of blocking D2 autoreceptors |
| disinhibition | The short term effect of blocking D2 postsynaptic receptors |
| increased inhibition | The long term effect of blocking D2 postsynaptic receptors |
| Gs | D1-like DA receptors are ___ coupled |
| Gi | D2-like DA receptors are ___ coupled |
| excitatory | D1-like DA receptors have an ___ effect |
| inhibitory | D2-like DA receptors have an ___ effect |
| mesolimbic/mesocortical | Antipsychotics are thought to ameliorate schizophrenia symptoms by acting on this dopamine pathway |
| nigrostriatal | Typical antipsychotics are thought to cause motor side effects by acting on this dopamine pathway |
| tuberoinfundibular | Typical antipsychotics are thought to cause endocrine side effects by acting on this dopamine pathway |
First Time Here?
Welcome to Quizlet, a fun, free place to study. Try these flashcards, find others to study, or make your own.