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5 Written questions

5 Multiple choice questions

  1. VEGF
    Osteoclasts are brought in with blood vessels (since they are monocytes after all)
    Osteoblasts also migrate from the bone collar to trabeculae
  2. Chondrocyte, osteoblast, osteoclast
    Growth Formation Resorption
  3. Regulator of osteocalcin promoter
    activated by RSK2 kinase
    knockout leads to osteogenesis (smaller/thinner bone)
    Without, have trouble importing amino acids (high protein diet can fix)
  4. Delay: Msx2, Runx2 haploinsufficiencies
    Acceleration: FGF, MSX2 activating mutations. twist haploinsufficiency
  5. Inactivated RSK2.
    ATF4 isn't turned on
    can't import AA or fully differentiate osteoblasts
    treated with high protein diet

4 True/False questions

  1. Jansen blomstrands chrondroplaysiaPTHrP mutation in receptor
    Severe dwarfism.
    But aren't little people soooooo cute?

          

  2. Proliferation of chrondrocytesVia sox9.
    Haploinsufficiency leads to dwarfism.

          

  3. Three stages of bone developmentSomites ~> Axial
    Lateral plate mesoderm ~> appendicular
    Cranial neural crest ~> craniofacial
    Monocyte ~> osteoclasts

          

  4. Where does bone come from?Chondrocyte, osteoblast, osteoclast
    Growth Formation Resorption

          

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