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5 Written Questions

5 Multiple Choice Questions

  1. From monocytes
    Osteoblasts secrete both OPG and RANKL
    OPG binds and inhibits RANKL
    RANKL causes osteoclast maturation
  2. Inactivated RSK2.
    ATF4 isn't turned on
    can't import AA or fully differentiate osteoblasts
    treated with high protein diet
  3. PTHrP mutation in receptor
    Severe dwarfism.
    But aren't little people soooooo cute?
  4. Runx2 ~> osteocalcin ~> osteoblast.
    Twist inhibits Runx2
    without it, no bone!
    (Runx2 is also for chondrocytes)
  5. Via sox9.
    Haploinsufficiency leads to dwarfism.

4 True/False Questions

  1. Vascularization of boneVia sox9.
    Haploinsufficiency leads to dwarfism.

          

  2. ATF4Regulator of osteocalcin promoter
    activated by RSK2 kinase
    knockout leads to osteogenesis (smaller/thinner bone)
    Without, have trouble importing amino acids (high protein diet can fix)

          

  3. Cleidocranial dysplasiaFrom monocytes
    Osteoblasts secrete both OPG and RANKL
    OPG binds and inhibits RANKL
    RANKL causes osteoclast maturation

          

  4. Basic bone cell typesInactivated RSK2.
    ATF4 isn't turned on
    can't import AA or fully differentiate osteoblasts
    treated with high protein diet

          

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