← Skeletal Growth Test
5 Written Questions
5 Multiple Choice Questions
- From monocytes
Osteoblasts secrete both OPG and RANKL
OPG binds and inhibits RANKL
RANKL causes osteoclast maturation
- Chondrocyte, osteoblast, osteoclast
Growth Formation Resorption
- Via sox9.
Haploinsufficiency leads to dwarfism.
- over-activated RSK2.
Too much ATF4 ~> osteoclacin ~> too many osteoblasts
- Runx2 ~> osteocalcin ~> osteoblast.
Twist inhibits Runx2
without it, no bone!
(Runx2 is also for chondrocytes)
4 True/False Questions
ATF4 → Regulator of osteocalcin promoter
activated by RSK2 kinase
knockout leads to osteogenesis (smaller/thinner bone)
Without, have trouble importing amino acids (high protein diet can fix)
Three stages of bone development → Patterning ~> Skeletogenesis ~> Homeostasis
Lethal Lethal 50% population problems
Jansen blomstrands chrondroplaysia → PTHrP mutation in receptor
But aren't little people soooooo cute?
Cleidocranial dysplasia → Runx2 haploinsufficiency
osteoblasts don't form and you have weak bones, no clavicle, and gap in skull