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5 Written Questions

5 Multiple Choice Questions

  1. PTHrP mutation in receptor
    Severe dwarfism.
    But aren't little people soooooo cute?
  2. Runx2 haploinsufficiency
    osteoblasts don't form and you have weak bones, no clavicle, and gap in skull
  3. From monocytes
    Osteoblasts secrete both OPG and RANKL
    OPG binds and inhibits RANKL
    RANKL causes osteoclast maturation
  4. Delay: Msx2, Runx2 haploinsufficiencies
    Acceleration: FGF, MSX2 activating mutations. twist haploinsufficiency
  5. Inactivated RSK2.
    ATF4 isn't turned on
    can't import AA or fully differentiate osteoblasts
    treated with high protein diet

4 True/False Questions

  1. ATF4Inactivated RSK2.
    ATF4 isn't turned on
    can't import AA or fully differentiate osteoblasts
    treated with high protein diet

          

  2. Three stages of bone developmentPatterning ~> Skeletogenesis ~> Homeostasis
    Dyostoses Dysplasia
    Lethal Lethal 50% population problems

          

  3. Basic bone cell typesChondrocyte, osteoblast, osteoclast
    Growth Formation Resorption

          

  4. Vascularization of boneVEGF
    Osteoclasts are brought in with blood vessels (since they are monocytes after all)
    Osteoblasts also migrate from the bone collar to trabeculae

          

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