space in which lungs develop and persist
Space in which heart develops and persists
space in which the abdominal viscera develops nad persists, heriation of small intestine and portion of large intestine
Will become the central tendon of the thoracic diaphragm, heart sits right on top of it.
It comes down with the pericardial cavity. the pericardial cavity sits on the central tendon of the diaphrarm.
Pleuroperiotneal fold grows forward to meet the septum tansversum.
The right sides closes up first, the left one closes up later.
When does the intraembryonic Coelom develop?
Develops during the 4th week, it is primordium of the embryonic body cavities, Horsehoe shaped cavity
The intraembryonic coelom is the first cavity to form in the embryo.
Before it forms, the embryo is just a flat disc with ectoderm, mesoderm and endoderm. Inside the mesoderm, cells start to breakdown and a space starts to develop.
Finally you get a horseshoe shaped cavity around the disc.
Pericardial Coelom is at the cranial end.
Pericardioperitoneal Canal is more lateral, superior to the peritoneal coelom, at the caudal end
Peritoneal Coelom cavity is lateral at the most caudal end of the U shape.
What does the cranial end the intraembryonic coelom develop into?
The future pericardial cavity
Embryo undergoes the head fold, which brings the pericardium and heart ventrocaudally to take its position anterior to the foregut.
Endoderm gets placed behind the heart due to taking in some of yolk sac.
The heart is at first infront the of the buccopharygeal membrane, site of the future mouth, then it moves inward and below.
Caudal limbs of the intraembryonic coelom?
Future pleural and periotenal cavities
Opens to the extraembryonic coelom. Accommodates the growth and movement of developing organs, loses connection with the extraembryonic coelom during the 10th week of development as the developing intestine return to the body cavity.
Embryo folds in the horizontal plane, Lateral folds, brings the two caudal limbs together ventrally, which then fuse to form the peritoneal cavity.
Pinches off the yolk sac which becomes the gut tube.
Results in a gut tube suspended between two layerso of membrane. The gut tube is suspended by dorsal mesentery and ventral mesentery which supplies the vasculature.
heart is is outside the body wall, head fold did not get there before lateral fold formed, sternum never develops, survival is poor.
Double layer of peritoneum that extends from the abdominal wall.
Conveys blood vessels, nerves and lymphatics to organs
Permanent structure, provides the route for vasculature, nerves and lymphatics to developing organs
remains attached to caudal part of the foregut (primordial liver, primoridal stomach and proximal part of duodenum
Becomes the falciform ligament and lesser omentum
Divides the peritoneal cavity into right and left halves
lies lateral to foregut (future esophagus)
Dorsal to Septum Transversum (future central tendon of the diaphragm
Partitions form in each canal due to developing bronchial buds-Cranial ridges and Caudal ridges.
Cranial Ridges of the Pericardioperitoneal canals
Pleurpericardial folds, located superior to developing lungs, separate pleural from pericardial cavities.
Pleuroperitoneal folds, located inferior to developing lungs, Separate pleural from peritoneal cavities
Enlargement of pleuropericardial folds becomes the parititions that separates the pleural from the pericardial cavities.
Myoblast migrate into pleuroperitoneal membranes from C3-C5 cervical myotomes carrying their nerves wtih them.
These nervers pierce the pleuropericardial membranes-in the adult located on the fibrous pericardium.
Contain the common cardinal veins-drain the primordial venous system into the sinus venosus of the primordial heart. And it also contains the phrenic nerve!!! Important.
Pleural cavities goes out first because the lungs need space to develop. As the bronchial buds mature into the lungs, they grow into the pleural cavity. Pleural cavities expand ventrally around the heart which splits the mesenchyme into the outer layer-thoracic wall and the inner layer-fibrous pericardium (pleuropericardial membrane)which contains the phrenic nerve.
The pericardial cavity should develop first, now what is left is the pleuroperiotneal membranes.
When does the primordial mediastinum form?
By the 7th week the pleuropericardial membranes have fused with the ventral mesenchyme forming the primordial mediastinum which contains all organs of the thoracic cavity except the lung and the pleura.
Enlargement of the pleuroperitoneal folds becomes the parition that separates the pleural from the peritoneal cavities.
During the 6th week, these membranes extend ventromedially and fuse with the dorsal mesnetery of the esophagus and the septum transversum, which separates the pleural cavity from the peritoneal cavity
The closure is assisted by the migration of myoblasts into the pleuroperitoneal membrane
Right side closes first, left side closes second. Problems can arise if the left side does not close.
Where does the Diaphragm develop from
Develops from the Septum Transversum, Pleuroperitoneal membranes, Dorsal mesentery of the esophagus, Muscular ingrowth from the lateral body walls, caused by pleural cavities expanding, innervated by intercostal nerves.
What it the diaphragm's innervation
C3, C4, C5 keeps the diaphragm alive from the cerival somites. Because of the cranial head fold, it brings the septum transversum close the cerivical somites, the diaphragm gets its innervation early.
As the lungs grow, and the heart grows, the diaphragm gets pushed down away from the cerivical region, but still keeps its innervation. This is why when the diaphragm it irritated (from the gall bladder inflamation etc), you might have referred pain in the shoulder bc it is the dermatome for C3-C5.
As the pleural cavity expands, growing faster than the lungs, it creates a costodiaphramtic recess inbetween the intercostals and the diaphragm. Here the diaphragm becomes innervated peripherally with intercostal nerves for sensory. Centrally it is still innervated by the phrenic for sensory. This is part of the muscular ingrowth.
Congential Diaphragmatic Hernia Posterolateral Defect
A failure of the diaphragm to completely close during development on the left side. Intestine will come up, and pt will have an underdeveloped left lung.
Congenital hiatal hernia
is the protrusion (or herniation) of the upper part of the stomach into the thorax through a tear or weakness in the diaphragm.
Has to do with the esophagus and the dorsal mesentery
As the esophagus mesentery develops, if muscle doesn't develop on the dorsal mesentery, then the stomach can eaily come up into the thoracic cavity, comes through the diaphragm.