Cardimyopathy & Heart Failure

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Dr. Nine - November 11, 2011 Semester 3, Mini 3

What is the most common form of cardiomyopathy?

dilated cardiomyopathy

What are underlying associations with dilated cardiomyopathy?

alcohol, obesity, pregnancy, sleep apnea

What are the histologic findings in dilated cardiomyopathy?

myofiber hypertrophy and disarray
"lacy" interstitial fibrosis

Genetic defects in what proteins can cause dilated cardiomyopathy?

dystrophin, desmin

What is the treatment for dilated cardiomyopathy besides heart transplant?

pacemaker

What type of cardiomyopathy can occur during or up to 6 months after pregnancy?

dilated cardiomyopathy

What type of cardiomyopathy has a 100% genetic cause and prominent left ventricle?

hypertrophic cardiomyopathy

Idiopathic hypertrophic subaortic stenosis is associated with what type of cardiomyopathy?

hypertrophic

Hypertrophic cardiomyopathy is associated with mutations in what protein?

sarcomeric myosin heavy chain, light chain

What type of cardiomyopathy is prominent in young athletes?

hypertrophic

What are the main causes of restrictive cardiomyopathy?

cardiac amyloidosis and endocardial fibroelastosis

What is cardiac amyloidosis?

build up of abnormal fibril in the heart muscle

What cardiac problem is seen in multiple myeloma?

cardiac amyloidosis

What stains apple-green birefringence with congo red?

cardiac amyloidosis

What age group is effected by endocardial fibroelastosis?

infants and young children

What is the hallmark feature of arrhythmogenic right ventricular cardiomyopathy?

fatty infiltration and fibrosis of right ventricular myocardium

What are the clinical features of arrhythmogenic right ventricular cardiomyopathy?

rare, autosomal dominant, can cause sudden death due to arrhythmia, right heart failure, young pts

What does left heart failure lead to?

pulmonary edema and congestion

In what type of heart failure are "heart failure cells" found?

left

What is "nutmeg" liver associated with?

right heart failure

What is right heart failure called when it occurs alone?

cor pulmonale

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