ch 3 part 2 oral diseases with immunologic pathogenesis and autoimmune disease

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57 terms · RED

what is the most common cause of an apthous ulcer

trauma

what type of immunity is an apthous ulcer?

cell mediated (no antibodies, involves the T cell)

where is a minor apthous ulcer located?

anterior of mouth

what type of apthous ulcer would be larger than 1 cm and in the posterior portion of the mouth?

major apthous ulcer

what type of apthous ulcer is in multiples and can be 1-2 mm in size and any location?

herpetiform apthous ucler (bacterial)

uticaria=

hives

pruritus=

itching

t/f there is no itching with angioedema

true

contact mucositis and dermatitis are ___ cell mediated and type ___ hypersensitivity

T cell
IV

fixed drug eruptions are type ____ hypersensitivity

III (humoral)

what disease is seen in young adult males and has a target bull's eye lesion

erythema multiforme

what is the most severe form of erythema multiforme?

stevens-johnson sx

what is the tx for stevens-johnson sx

topical steriods
systemic corticostorids

where are the ulcers seen in the oral cavity with erythema multiforme

lateral border of tongue

which disease is characterized by lacey striae or wickham's striae?

lichen planus

what is the most common location of lichen planus?

buccal mucosa

what is the most common type of lichen planus?

reticular lichen planus (has wickham's striae)

lichen planus is composed of tooth shaped ____ ___

rete ridges

what is the classic triad for reactive arthritis/reiter sx

arthritis
urethritis
conjuctivitis

what disease is the antigen marker HLA-B27 seen in?

reactive arthritis/reiter sx

what are langerhans cells a type of?

macrophage

langerhans cells are a part of what type of immunity?

cell mediated

what are the two forms of langerhans cell disease?

letterer-siwe disease
hand-schuller-christian disease

what is the acute disseminated form of langerhans cell disease

letterer-siwe disease

what is the chronic disseminated form of langerhans cell disease?

hand-schuller-christian disease

which type of langerhans cell disease is in older children and shows a punched out radiolucencies in skull?

hand-schuller-christian disease

what is the triad for hand-schuller-christian disease?

punched out (radiolucencies of skull)
exophthalmo
diabetes insipidus

what type of sjogren sx involves the eyes and mouth only?

primary sjogren sx

what type of sjogren sx invloves other autoimmune dz such as rheumatoid arthritis and lupus erythematous

secondary sjogren sx

what type of immunity is involved with sjogren sx

cellular and humoral

sjogren sx has _____ and _____

xerostomia
xerophtalmia

sjogren sx has a gneralized loss of ____ and ____ papillae

fungiform
filiform

sjogren sx has a high risk for _____, _____ ____ and ______

caries
periodontal dz
candidiasis

what sx is raynaud phenomenon associated with?

sjogren sx

what % of pt are positive for the rheumatoid factor?

90%

what sx is rheumatoid factor associated with?

sjogren sx

what antibody is positive in sjogren sx

IgG

what three things do you treat with sjogren sx

arthritis (NSAIDs, corticosteroids)
xerostomia
keratoconjunctivitis sicca (artificial tears)

systmeic lupus erythematosus is a ____ sx

true

what dz is associated with the butterfly rash on the nose?

systemic lupus erythematosus

what are the common manifestations of SLE?

arthritis/arthralgia

what does SLE resemble when biopsied?

lichen planus

what must you do before tx with a pt who has SLE?

consult physician (antibiotic for endocarditis, watch epi or levo)

what is the prognosis for moderate to severe SLE?

fatal (due to renal failure)

what dz is seen in ashkenazi jews and the first sign of the dz is in the oral cavity?

pemphiGUS vulgaris

what is the breakdown of cellular adhesion between epithelial cells?

acanthosis

which dz has a intraepithelial blishter known as acanthosis?

pemphiGUS bulgaris

which dz has nickolsy's signs and tzanck cells?

pemphiGUS vulgaris

where are antibodies identified with pemphiGUS vulgaris?

prickle cell layer

t/f pemphiGUS destroys hemidesmosomes

false (destroys desmosomes)

where is the most common location for mucous membrane pemphiGOID?

gingiva

mucous membrane pemphiGOID and ______ gingivitis and _____ sign

desquamative gingivitis
nikolsky sign

t/f the tx for phempiGUS includes direct and indirect immunofluorescence

true

does indirect immunofluorescence help with Dx of mucoous membrane pemphiGOID

no (there are no circulating autoantibodies)

what is the differnece between pemphigus and pemphigoid?

no circulating autoantiboides in pemphigoid

what dz is seen in mediterranean and asian people

behcet syndrome

what are the chronic recurrent autoimmune diseases of behcet syndrome?

oral ulcers
genital ulcers
occular inflammation

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