Neoplasia 6: Mutations: Anti-apoptosis genes

Created by DrPeanut 

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13 terms

What is the main ANTI APOPTOTIC GENE?

BCL-2 GENE

BCL-2 gene products normally ___________ by ___________

- prevents cell from undergoing apoptosis
- blocking the mitochondrial permeability transmembrane channels so that CYTOCHROME C won't leak out into the cytoplasm triggering APOPTOSIS

mutation of BCL-2 gene will cause _______ of the gene

OVER EXPRESSION of the gene

over-expression of the gene will lead to cells becoming _________

IMMORTAL

BCL-2 mutation is associated with

B cell follicular lymphoma

_______ causes over-expression of BCL-2 gene products --> ________

translocation t(14:18)
prevents apoptosis of B lymphocytes

MC malignant lymphoma

B cell follicular lymphoma

Burkitt's lymphoma

C-myc (protooncogene) - transcription
t(8;14)

CML - chronic myelogenous leukemia

ABL (protooncogene) - tyrosine kinase activity
t(9;22)

B Follicular Lymphoma

BCL2 (anti-apoptosis)
t(14;18)

Acute Promyelocytic leukemia

t(15;17)

Hodgkin's lymphoma is a cancer of the _________ cells

Reed S. cells

Non-Hodgkin's lymphoma arise from ___ and ____

B and C lymphocytes

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