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5 Written questions

5 Matching questions

  1. side effects of glycopeptide
  2. other pcn sub., along w macrocodes
  3. intermediate acting Tetracyclines
  4. common macrolide agents
  5. pharmacokinetics of aminoglycosides
  1. a -erthromycin (iv)
    -clarithromycin
    -azithromycin (long 1/2 life) (iv)
    -dirithromycin
  2. b -vanocomycin
    -s/e: nephrotoxicity, ototoxicity damage (8th cranial nerve) can be permanent or temp, chills, dizziness, fever, rash, n/v
  3. c -lincosamides
    -gylcopeptides
    -ketolides
  4. d -IM/IV
    -shot half life; given 3-4 days daily
    -excreted via urine
  5. e -PO only
    -declomycin

5 Multiple choice questions

  1. - due to too rapid of an infusion of glycopeptide
    -red blotching of face/neck/chest
    -toxic not allergic rxn
    -no need to stop infusion, lower infusion rate
  2. -structurally related to macrocodes
    -ketek: (18+) treats mild to moderate CAP
    -adverse rxn: may lead to an exacerbation of myashenia gravis
    -many drug interactions
  3. -bacteriostatic
    -used in combination to treat h.pylori
    -resistance has increased in treatment of pneumococcal and gonococcal infections
    -orally use mainly
    -available in IV/IM- rare cause of pain
    -not to be taken with magnesium/aluminum antacid preparations, calcium containing products.- prevents absorption
  4. -oral: treats antibiotic associated pseudomembranous colitis due to c.diff
    -IV: treats severe infections due to MRSA; septicemia; bone, skin, lower reps tract infect that are resistant to other antibiotics
    -t-1/2 life: 6 hrs
    -excretion via urine
  5. -readily absorbed from the GI tract; excretion in bile, feces, urine
    -only a small amy is excreted in urine, therefore renal insufficiency is not a contraindication for macrolide use

5 True/False questions

  1. glycopeptides-sub cat of macrolide
    -focus of vancomycin
    -bactericidal
    -used against drug-resistant s.aureus and cardiac surf prophylaxis w pt with PCN allergy

          

  2. pharmacodynamics of Fluoroquinolones-inhibits bacterial DNA synthesis by inhibiting the enzyme DNA gyrase
    -effect of oral hypoglycemics, theophylline and caffeine are increased with concurrent use of a Fluoroquinolones
    -peak con: 1-2 hrs

          

  3. side effects/adverse run of macrolide-gi n/v/d/ abdominal cramping
    -allergic rn are rare
    -when combined with other hepatotoxic drugs leads to hepatotoxicity; usually reversible when the drug is discnt.

          

  4. pharmacokinetics of ketolides-readily absorbed from the GI tract; excretion in bile, feces, urine
    -only a small amy is excreted in urine, therefore renal insufficiency is not a contraindication for macrolide use

          

  5. aminoglycosides-sub cat of macrolide
    -bacteriostatic/cidal
    -clindamycin: activate against most gram + and anaerobic org., absorbed better than lincocin vis gi tract, maintains a higher serum drug conc and fewer toxic effects
    -lincomycin
    -s/e: gi upset, rash
    -adverse rxn: colitis, anaphylactic shock
    -drug interactions: aminophyline, dilantin, barbiturates, ampicillin

          

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