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5 Written questions

5 Matching questions

  1. other pcn sub., along w macrocodes
  2. pharmacodynamics of glycopeptides
  3. pharmacodynaamics of ketolides
  4. Tetracyclines
  5. photosensitivity
  1. a inhibits cell wall synthesis; active against several gr + bacteria; peaks 30min after IV infusion
  2. b -lincosamides
    -gylcopeptides
    -ketolides
  3. c -bacteriostatic
    -used in combination to treat h.pylori
    -resistance has increased in treatment of pneumococcal and gonococcal infections
    -orally use mainly
    -available in IV/IM- rare cause of pain
    -not to be taken with magnesium/aluminum antacid preparations, calcium containing products.- prevents absorption
  4. d -increase risk with declomycin and long acting forms.
    -get sun-burnt 10x worse than average
  5. e -inhibits protein synethsis in m.o by binding to ribosomal RNA which leads to bacterial cell death
    -peak action 1 hr

5 Multiple choice questions

  1. -all inhibit protein synthesis
    -clarithromycin: 2x a day (BID)
    -azitromycin: QD x 5 days; t-1/2= 50 hours
  2. -bactericidal
    -preg cat. C
    -onset of action: immediate
    -peak action: 1-2 hrs
  3. -IM/IV
    -shot half life; given 3-4 days daily
    -excreted via urine
  4. -interferes with enzyme DNA gyrase- needed to synthesize bacterial DNA
    -bactericidal on gram + and -
    -mainly used for tx of UTI, bone, joint infect; bronchitis, pneumonia, gastroenteritis, gonorrhea
    -high tissue distribution
    -food/antacids slow absorption rate
  5. -PO only
    -Sumycin

5 True/False questions

  1. macrolides-structurally related to macrocodes
    -ketek: (18+) treats mild to moderate CAP
    -adverse rxn: may lead to an exacerbation of myashenia gravis
    -many drug interactions

          

  2. common examples of Fluoroquinolones-inhibits bacterial DNA synthesis by inhibiting the enzyme DNA gyrase
    -effect of oral hypoglycemics, theophylline and caffeine are increased with concurrent use of a Fluoroquinolones
    -peak con: 1-2 hrs

          

  3. avelox-more active against s. pneumoniae than levaquin is

          

  4. long acting tetracyclines-PO only
    -Sumycin

          

  5. pharmacodynamics of Fluoroquinolones-well absorbed from GI tract
    -low protein binding effect
    -moderate half life: 6-8 hrs
    -excreted via urine

          

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