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5 Written questions

5 Matching questions

  1. pharmacodynamics of macrocodes
  2. long acting tetracyclines
  3. macrolides
  4. extended macrolides
  5. other pcn sub., along w macrocodes
  1. a -PO and IV
    -Vibramycin
    -minocin
  2. b -all inhibit protein synthesis
    -clarithromycin: 2x a day (BID)
    -azitromycin: QD x 5 days; t-1/2= 50 hours
  3. c -lincosamides
    -gylcopeptides
    -ketolides
  4. d -bacteriostatic
    -oral prepL onset of action 1 h, peak conc is 4 hrs and duration is 6hrs
  5. e -bacteriostatic; with high doses can be bactericidal
    -used as pen sub.; diff in structure of pen
    -broad spectrum
    -used to treat mild-moderate infection of reps tract, sinuses, gi tract, skin, soft tissue, impetigo and STI
    -PO, slow IV
    -e-mycin drug of choice for Legionnaires mycoplasmal pneumonia

5 Multiple choice questions

  1. -oral: treats antibiotic associated pseudomembranous colitis due to c.diff
    -IV: treats severe infections due to MRSA; septicemia; bone, skin, lower reps tract infect that are resistant to other antibiotics
    -t-1/2 life: 6 hrs
    -excretion via urine
  2. -inhibits protein synethsis in m.o by binding to ribosomal RNA which leads to bacterial cell death
    -peak action 1 hr
  3. -gi n/v/d/ abdominal cramping
    -allergic rn are rare
    -when combined with other hepatotoxic drugs leads to hepatotoxicity; usually reversible when the drug is discnt.
  4. -gi disturbances, photosensitivity, teratogenic effects (1st and 3rd), nephrotoxicity, superinfection, oral contraception may be decreased
  5. -primarly treats URIs, acute sinusitis, chronic bronchitis, UTIs.
    -may cause dysrhythmias

5 True/False questions

  1. side effects of glycopeptide-vanocomycin
    -s/e: nephrotoxicity, ototoxicity damage (8th cranial nerve) can be permanent or temp, chills, dizziness, fever, rash, n/v

          

  2. intermediate acting Tetracyclines-PO only
    -declomycin

          

  3. pharmacodynamics of glycopeptides-oral: treats antibiotic associated pseudomembranous colitis due to c.diff
    -IV: treats severe infections due to MRSA; septicemia; bone, skin, lower reps tract infect that are resistant to other antibiotics
    -t-1/2 life: 6 hrs
    -excretion via urine

          

  4. ketolides-bacteriostatic; with high doses can be bactericidal
    -used as pen sub.; diff in structure of pen
    -broad spectrum
    -used to treat mild-moderate infection of reps tract, sinuses, gi tract, skin, soft tissue, impetigo and STI
    -PO, slow IV
    -e-mycin drug of choice for Legionnaires mycoplasmal pneumonia

          

  5. pharmacokinetics of macrolides-readily absorbed from the GI tract; excretion in bile, feces, urine
    -only a small amy is excreted in urine, therefore renal insufficiency is not a contraindication for macrolide use

          

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