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5 Written Questions

5 Matching Questions

  1. side effects of glycopeptide
  2. pharmacokinetics of macrolides
  3. macrolides
  4. photosensitivity
  5. pharmacokinetics of aminoglycosides
  1. a -increase risk with declomycin and long acting forms.
    -get sun-burnt 10x worse than average
  2. b -IM/IV
    -shot half life; given 3-4 days daily
    -excreted via urine
  3. c -readily absorbed from the GI tract; excretion in bile, feces, urine
    -only a small amy is excreted in urine, therefore renal insufficiency is not a contraindication for macrolide use
  4. d -vanocomycin
    -s/e: nephrotoxicity, ototoxicity damage (8th cranial nerve) can be permanent or temp, chills, dizziness, fever, rash, n/v
  5. e -bacteriostatic; with high doses can be bactericidal
    -used as pen sub.; diff in structure of pen
    -broad spectrum
    -used to treat mild-moderate infection of reps tract, sinuses, gi tract, skin, soft tissue, impetigo and STI
    -PO, slow IV
    -e-mycin drug of choice for Legionnaires mycoplasmal pneumonia

5 Multiple Choice Questions

  1. -PO only
    -declomycin
  2. - due to too rapid of an infusion of glycopeptide
    -red blotching of face/neck/chest
    -toxic not allergic rxn
    -no need to stop infusion, lower infusion rate
  3. -bacteriostatic
    -oral prepL onset of action 1 h, peak conc is 4 hrs and duration is 6hrs
  4. -inhibits protein synethsis in m.o by binding to ribosomal RNA which leads to bacterial cell death
    -peak action 1 hr
  5. -more active against s. pneumoniae than levaquin is

5 True/False Questions

  1. glycopeptides-sub cat of macrolide
    -bacteriostatic/cidal
    -clindamycin: activate against most gram + and anaerobic org., absorbed better than lincocin vis gi tract, maintains a higher serum drug conc and fewer toxic effects
    -lincomycin
    -s/e: gi upset, rash
    -adverse rxn: colitis, anaphylactic shock
    -drug interactions: aminophyline, dilantin, barbiturates, ampicillin

          

  2. side effects and adverse effects to tetracyclines-gi n/v/d/ abdominal cramping
    -allergic rn are rare
    -when combined with other hepatotoxic drugs leads to hepatotoxicity; usually reversible when the drug is discnt.

          

  3. lincosamides-sub cat of macrolide
    -focus of vancomycin
    -bactericidal
    -used against drug-resistant s.aureus and cardiac surf prophylaxis w pt with PCN allergy

          

  4. pharmcokinetics of Fluoroquinolones-well absorbed from GI tract
    -low protein binding effect
    -moderate half life: 6-8 hrs
    -excreted via urine

          

  5. macrolide drug interactions-bacteriostatic; with high doses can be bactericidal
    -used as pen sub.; diff in structure of pen
    -broad spectrum
    -used to treat mild-moderate infection of reps tract, sinuses, gi tract, skin, soft tissue, impetigo and STI
    -PO, slow IV
    -e-mycin drug of choice for Legionnaires mycoplasmal pneumonia

          

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