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Macroglides, tetracyclines, aminoglcosides and fluroquinolones pharm test #2 Test

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5 Written Questions

5 Matching Questions

  1. pharmacodynamics of glycopeptides
  2. photosensitivity
  3. extended macrolides
  4. ketolides
  5. cipro
  1. a -increase risk with declomycin and long acting forms.
    -get sun-burnt 10x worse than average
  2. b inhibits cell wall synthesis; active against several gr + bacteria; peaks 30min after IV infusion
  3. c -broad spectrum of action; lower respitory infections, UTIs, bone, skin
  4. d -all inhibit protein synthesis
    -clarithromycin: 2x a day (BID)
    -azitromycin: QD x 5 days; t-1/2= 50 hours
  5. e -structurally related to macrocodes
    -ketek: (18+) treats mild to moderate CAP
    -adverse rxn: may lead to an exacerbation of myashenia gravis
    -many drug interactions

5 Multiple Choice Questions

  1. -sub cat of macrolide
    -focus of vancomycin
    -bactericidal
    -used against drug-resistant s.aureus and cardiac surf prophylaxis w pt with PCN allergy
  2. -vanocomycin
    -s/e: nephrotoxicity, ototoxicity damage (8th cranial nerve) can be permanent or temp, chills, dizziness, fever, rash, n/v
  3. -oral: treats antibiotic associated pseudomembranous colitis due to c.diff
    -IV: treats severe infections due to MRSA; septicemia; bone, skin, lower reps tract infect that are resistant to other antibiotics
    -t-1/2 life: 6 hrs
    -excretion via urine
  4. -readily absorbed from the GI tract; excretion in bile, feces, urine
    -only a small amy is excreted in urine, therefore renal insufficiency is not a contraindication for macrolide use
  5. -inhibits protein synethsis in m.o by binding to ribosomal RNA which leads to bacterial cell death
    -peak action 1 hr

5 True/False Questions

  1. side effects and adverse effects to tetracyclines-gi disturbances, photosensitivity, teratogenic effects (1st and 3rd), nephrotoxicity, superinfection, oral contraception may be decreased

          

  2. long acting tetracyclines-PO and IV
    -Vibramycin
    -minocin

          

  3. macrolide drug interactions-bacteriostatic; with high doses can be bactericidal
    -used as pen sub.; diff in structure of pen
    -broad spectrum
    -used to treat mild-moderate infection of reps tract, sinuses, gi tract, skin, soft tissue, impetigo and STI
    -PO, slow IV
    -e-mycin drug of choice for Legionnaires mycoplasmal pneumonia

          

  4. pharmacodynamics of aminoglycosides-bactericidal
    -preg cat. C
    -onset of action: immediate
    -peak action: 1-2 hrs

          

  5. Fluoroquinolones-interferes with enzyme DNA gyrase- needed to synthesize bacterial DNA
    -bactericidal on gram + and -
    -mainly used for tx of UTI, bone, joint infect; bronchitis, pneumonia, gastroenteritis, gonorrhea
    -high tissue distribution
    -food/antacids slow absorption rate

          

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