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5 Written Questions

5 Matching Questions

  1. red neck (man) syndrome
  2. macrolides
  3. short acting tetracyclines
  4. pharmacodynamics of glycopeptides
  5. side effects of glycopeptide
  1. a -bacteriostatic; with high doses can be bactericidal
    -used as pen sub.; diff in structure of pen
    -broad spectrum
    -used to treat mild-moderate infection of reps tract, sinuses, gi tract, skin, soft tissue, impetigo and STI
    -PO, slow IV
    -e-mycin drug of choice for Legionnaires mycoplasmal pneumonia
  2. b -PO only
    -Sumycin
  3. c - due to too rapid of an infusion of glycopeptide
    -red blotching of face/neck/chest
    -toxic not allergic rxn
    -no need to stop infusion, lower infusion rate
  4. d inhibits cell wall synthesis; active against several gr + bacteria; peaks 30min after IV infusion
  5. e -vanocomycin
    -s/e: nephrotoxicity, ototoxicity damage (8th cranial nerve) can be permanent or temp, chills, dizziness, fever, rash, n/v

5 Multiple Choice Questions

  1. -inhibits bacterial DNA synthesis by inhibiting the enzyme DNA gyrase
    -effect of oral hypoglycemics, theophylline and caffeine are increased with concurrent use of a Fluoroquinolones
    -peak con: 1-2 hrs
  2. -sub cat of macrolide
    -focus of vancomycin
    -bactericidal
    -used against drug-resistant s.aureus and cardiac surf prophylaxis w pt with PCN allergy
  3. -PO only
    -declomycin
  4. -structurally related to macrocodes
    -ketek: (18+) treats mild to moderate CAP
    -adverse rxn: may lead to an exacerbation of myashenia gravis
    -many drug interactions
  5. -readily absorbed from the GI tract; excretion in bile, feces, urine
    -only a small amy is excreted in urine, therefore renal insufficiency is not a contraindication for macrolide use

5 True/False Questions

  1. macrolide drug interactions-bacteriostatic; with high doses can be bactericidal
    -used as pen sub.; diff in structure of pen
    -broad spectrum
    -used to treat mild-moderate infection of reps tract, sinuses, gi tract, skin, soft tissue, impetigo and STI
    -PO, slow IV
    -e-mycin drug of choice for Legionnaires mycoplasmal pneumonia

          

  2. common macrolide agents-erthromycin (iv)
    -clarithromycin
    -azithromycin (long 1/2 life) (iv)
    -dirithromycin

          

  3. cipro-broad spectrum of action; lower respitory infections, UTIs, bone, skin

          

  4. other pcn sub., along w macrocodes-lincosamides
    -gylcopeptides
    -ketolides

          

  5. pharmacodynaamics of ketolides-inhibits protein synethsis in m.o by binding to ribosomal RNA which leads to bacterial cell death
    -peak action 1 hr

          

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