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5 Written Questions

5 Matching Questions

  1. common examples of Fluoroquinolones
  2. macrolide drug interactions
  3. pharmacokinetics of glycopeptides
  4. pharmacokinetics of aminoglycosides
  5. macrolides
  1. a -bacteriostatic; with high doses can be bactericidal
    -used as pen sub.; diff in structure of pen
    -broad spectrum
    -used to treat mild-moderate infection of reps tract, sinuses, gi tract, skin, soft tissue, impetigo and STI
    -PO, slow IV
    -e-mycin drug of choice for Legionnaires mycoplasmal pneumonia
  2. b -oral: treats antibiotic associated pseudomembranous colitis due to c.diff
    -IV: treats severe infections due to MRSA; septicemia; bone, skin, lower reps tract infect that are resistant to other antibiotics
    -t-1/2 life: 6 hrs
    -excretion via urine
  3. c -IM/IV
    -shot half life; given 3-4 days daily
    -excreted via urine
  4. d -cipro
    -levaquin
    -avelox
  5. e may increase serum levels of:
    -theophyline
    -carbamazepine
    -warfarin
    -do not administer with antacids bc may increase peak levels of macrolide

5 Multiple Choice Questions

  1. -inhibits bacterial protein synthesis
    -gram - bact
    -reserved for serious infections
    -not absorbedvia GI tract; does not cross BBB
    -IM/IV only
    -gentamycin, tobramycin, amikacin, streptomycin
    -s/e: ototoxicity, nephrotoxicity, superinfection
    -peak levels drawn to monitor toxicity
    -troug levels to monitor maintenance of therapeutic drug levee
  2. -vanocomycin
    -s/e: nephrotoxicity, ototoxicity damage (8th cranial nerve) can be permanent or temp, chills, dizziness, fever, rash, n/v
  3. inhibits cell wall synthesis; active against several gr + bacteria; peaks 30min after IV infusion
  4. -inhibits bacterial DNA synthesis by inhibiting the enzyme DNA gyrase
    -effect of oral hypoglycemics, theophylline and caffeine are increased with concurrent use of a Fluoroquinolones
    -peak con: 1-2 hrs
  5. -erthromycin (iv)
    -clarithromycin
    -azithromycin (long 1/2 life) (iv)
    -dirithromycin

5 True/False Questions

  1. avelox-more active against s. pneumoniae than levaquin is

          

  2. pharmacokinetics of macrolides-readily absorbed from the GI tract; excretion in bile, feces, urine
    -only a small amy is excreted in urine, therefore renal insufficiency is not a contraindication for macrolide use

          

  3. lincosamides-structurally related to macrocodes
    -ketek: (18+) treats mild to moderate CAP
    -adverse rxn: may lead to an exacerbation of myashenia gravis
    -many drug interactions

          

  4. glycopeptides-sub cat of macrolide
    -focus of vancomycin
    -bactericidal
    -used against drug-resistant s.aureus and cardiac surf prophylaxis w pt with PCN allergy

          

  5. red neck (man) syndrome- due to too rapid of an infusion of glycopeptide
    -red blotching of face/neck/chest
    -toxic not allergic rxn
    -no need to stop infusion, lower infusion rate

          

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