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5 Written Questions

5 Matching Questions

  1. Fluoroquinolones
  2. short acting tetracyclines
  3. pharmcokinetics of Fluoroquinolones
  4. levaquin
  5. red neck (man) syndrome
  1. a - due to too rapid of an infusion of glycopeptide
    -red blotching of face/neck/chest
    -toxic not allergic rxn
    -no need to stop infusion, lower infusion rate
  2. b -primarly treats URIs, acute sinusitis, chronic bronchitis, UTIs.
    -may cause dysrhythmias
  3. c -well absorbed from GI tract
    -low protein binding effect
    -moderate half life: 6-8 hrs
    -excreted via urine
  4. d -interferes with enzyme DNA gyrase- needed to synthesize bacterial DNA
    -bactericidal on gram + and -
    -mainly used for tx of UTI, bone, joint infect; bronchitis, pneumonia, gastroenteritis, gonorrhea
    -high tissue distribution
    -food/antacids slow absorption rate
  5. e -PO only
    -Sumycin

5 Multiple Choice Questions

  1. -cipro
    -levaquin
    -avelox
  2. -inhibits bacterial DNA synthesis by inhibiting the enzyme DNA gyrase
    -effect of oral hypoglycemics, theophylline and caffeine are increased with concurrent use of a Fluoroquinolones
    -peak con: 1-2 hrs
  3. -oral: treats antibiotic associated pseudomembranous colitis due to c.diff
    -IV: treats severe infections due to MRSA; septicemia; bone, skin, lower reps tract infect that are resistant to other antibiotics
    -t-1/2 life: 6 hrs
    -excretion via urine
  4. -increase risk with declomycin and long acting forms.
    -get sun-burnt 10x worse than average
  5. -gi disturbances, photosensitivity, teratogenic effects (1st and 3rd), nephrotoxicity, superinfection, oral contraception may be decreased

5 True/False Questions

  1. avelox-broad spectrum of action; lower respitory infections, UTIs, bone, skin

          

  2. other pcn sub., along w macrocodes-bacteriostatic
    -oral prepL onset of action 1 h, peak conc is 4 hrs and duration is 6hrs

          

  3. common macrolide agents-bacteriostatic; with high doses can be bactericidal
    -used as pen sub.; diff in structure of pen
    -broad spectrum
    -used to treat mild-moderate infection of reps tract, sinuses, gi tract, skin, soft tissue, impetigo and STI
    -PO, slow IV
    -e-mycin drug of choice for Legionnaires mycoplasmal pneumonia

          

  4. cipro-broad spectrum of action; lower respitory infections, UTIs, bone, skin

          

  5. extended macrolides-all inhibit protein synthesis
    -clarithromycin: 2x a day (BID)
    -azitromycin: QD x 5 days; t-1/2= 50 hours

          

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