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5 Written questions

5 Matching questions

  1. pharmacodynamics of glycopeptides
  2. pharmcokinetics of Fluoroquinolones
  3. pharmacodynamics of macrocodes
  4. other pcn sub., along w macrocodes
  5. levaquin
  1. a inhibits cell wall synthesis; active against several gr + bacteria; peaks 30min after IV infusion
  2. b -lincosamides
  3. c -well absorbed from GI tract
    -low protein binding effect
    -moderate half life: 6-8 hrs
    -excreted via urine
  4. d -bacteriostatic
    -oral prepL onset of action 1 h, peak conc is 4 hrs and duration is 6hrs
  5. e -primarly treats URIs, acute sinusitis, chronic bronchitis, UTIs.
    -may cause dysrhythmias

5 Multiple choice questions

  1. -bacteriostatic
    -used in combination to treat h.pylori
    -resistance has increased in treatment of pneumococcal and gonococcal infections
    -orally use mainly
    -available in IV/IM- rare cause of pain
    -not to be taken with magnesium/aluminum antacid preparations, calcium containing products.- prevents absorption
  2. -sub cat of macrolide
    -clindamycin: activate against most gram + and anaerobic org., absorbed better than lincocin vis gi tract, maintains a higher serum drug conc and fewer toxic effects
    -s/e: gi upset, rash
    -adverse rxn: colitis, anaphylactic shock
    -drug interactions: aminophyline, dilantin, barbiturates, ampicillin
  3. -cipro
  4. -inhibits bacterial DNA synthesis by inhibiting the enzyme DNA gyrase
    -effect of oral hypoglycemics, theophylline and caffeine are increased with concurrent use of a Fluoroquinolones
    -peak con: 1-2 hrs
  5. -gi n/v/d/ abdominal cramping
    -allergic rn are rare
    -when combined with other hepatotoxic drugs leads to hepatotoxicity; usually reversible when the drug is discnt.

5 True/False questions

  1. side effects of glycopeptide-oral: treats antibiotic associated pseudomembranous colitis due to c.diff
    -IV: treats severe infections due to MRSA; septicemia; bone, skin, lower reps tract infect that are resistant to other antibiotics
    -t-1/2 life: 6 hrs
    -excretion via urine


  2. cipro-broad spectrum of action; lower respitory infections, UTIs, bone, skin


  3. pharmacodynamics of aminoglycosides-bactericidal
    -preg cat. C
    -onset of action: immediate
    -peak action: 1-2 hrs


  4. pharmacodynaamics of ketolides-orally: absorption by GI tract
    -not affected by food intake
    -excreted through feces, urine
    -t-1/2: 10 hrs


  5. side effects and adverse effects to tetracyclines-gi disturbances, photosensitivity, teratogenic effects (1st and 3rd), nephrotoxicity, superinfection, oral contraception may be decreased


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