Ch. 14 DNA and Gene: Synthesis and Repair

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Created by:

eike2011  on November 22, 2011

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biology

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Ch. 14 DNA and Gene: Synthesis and Repair

double helix
double stranded molecule
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double helix double stranded molecule
complementary base pairing A&T, C&G
genome entire complement of DNA
DNA Polymerase polymerizes deoxyribionucleotides to DNA
origin of replication the replication bubble forms at a specific sequence of bases
replication fork y-shaped region where the parent-DNA double helix is split into two single strands
leading strand, or continuous strand leads into the replication fork and is synthesized continuously
lagging strand, or discontinuous strand lags behind the synthesis occurring in the fork
Okazaki fragments short sections about 1000 base pairs long
DNA ligase formation of a phosphodiester bond between fragments
replisome all the enzymes required for DNA synthesis organized into a machine
telomere the region at the end of a chromosome
telomerase catalyzes the synthesis of DNA from an RNA template. Acts as a built in template allowing telomerase to add DNA onto the end of a chromosomes and prevent it from getting shorter
proofread DNA polymerase- if the wrong base is added during DNA synthesis, the enzyme pauses, removes the mismatched base that was just added, and then proceeds with synthesis
mismatch repair occurs when mismatched bases are corrected after the DNA synthesis is complete
necleotide extension repair process of removing a damaged region in in one strand of DNA and correctly replacing it using the undamaged strand as a template

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eike2011