What are the clinical signs of hypothyroidism?
-Overweight, exercise intolerance
What is hypertricosis?
Abnormal hair growth; in the hypothyroid patient, hair is suspended in telogen.
What are some dermal abnormalities that can occur with hypothyroidism?
Excessive skin folds (noticeable around eyes)
Hyperkeratosis (with secondary pruritis)
Name some signs of congenital hypothyroidism.
TAPS (thick as pig ****)
Impaired cerebral development
Failure of permanent dentition to erupt
Epiphyseal dysgenesis (unable to grow from epiphyseal growth centers)
How do you diagnose hypothyroidism?
Basal total T4
Basal free T4
TRH response test
TSH response test
What can cause a decrease in basal T4?
Can basal T4 be normal in a dog with clinically overt hypothyroidism?
What can hypothyroidism be caused by?
1. Destruction of the thyroid gland or impaired thyroid hormone synthesis (primary)
2. Impaired secretion of TSH (secondary)
Which is more common: primary or secondary hypothyroidism?
Primary; more than 95% of cases are due to primary.
Is immune-mediated destruction of the thyroid in dogs common?
Yes, 50% of primary hypothyroid cases occur due to immune mediated destruction.