Desmopressin - MOA
Acts on the kidney to increase reabsorption of water
Desmopressin - Uses
ADH replacement for use in treating diabetes insipidus
Desmopressin - Side effects
- water intoxication
- thromboembolic disorder
Thyroid Hormone Replacement
Levothyroxine - MOA, uses
same as endogenous hormone
Levothyroxine- Side effects
propylthiouracil - MOA
Blcoks the synthesis of Thyroid Hormone and inhibits the incorporation of iodine into T3 and T4
propylthiouracil - Uses
propylthiouracil - Side effects
hydrocortisone - MOA
replaces physiologic levels of glucocorticoid
hydrocortisone - Uses
hydrocortisone - Side effects
- impaired wound healing
- peptic ulcers
- adrenal atrophy
- a million other things
Antiadreanl drugs treat?
Severe Cushing's syndrome
Drugs for Diabetes
Type 1 must be treated with insuline
type 2 may need insuline
Short acting hypoglycemic drug
Human regular Insulin (Humulin)
Humulin - MOA
promotes the entry of glucose into cells
the only insullin that can be injected
Humulin - Uses
short acting insuline, quickly decreases blood glucose
- also for emergency managment of ketoacidosis
Humulin - Side effects
Oral Hypoglycemic Drug; biguanide
Metformin - MOA
Decreases hepatic gluconeogenesis, mechanism unknown
Metformin - Uses
Type 2 diabetes; controls hyperglycemia
* Can be used alone or with other oral hypoglycemics
Metformin- Side effects
- lactic acidosis
Explain the pharmacotherapy for hypothyroidism and hyperthyroidism.
Hypersecretion = Graves Disease; PTU, Tapazole, 1-131
Hyposecretion = myxedema; thyroid hormone
Explain the pharmacotherapy for adrenal cortex disorders.
Hypersecretion of cluccorticiodes = cushings syndrome: antiadrenal agents
Hyposecretion of glucocorticiods= Addison's: gluccocorticiods
what are the electrolyte imbalances pertaining to glucocorticoids?
What are the administration alerts pertaining to glucocorticoids?
- must be taken at the same time every day
- give with food
What are the admin. alerts pertaining to administering desmopressin intranasally?
- rotate nasal spray bottle before spraying but DON'T shake it
- store spray at room temp.
- use spray in the morning at the same time of day
List the signs of hypoglycemia
List the signs of hyperglycemia
- Weight loss
What is the nursing priority action if you find a patient unresponsive after the patient has received insulin?
Treat with IV or parenteral glucose
How do you properly store insulin vials?
- Store at room temperature
- Avoid direct sunlight/heat
- Opened vials can be stored at room temp. for 1 month
- Discard vial if there is nay noticable visiual change
How do you ensure the correct insulin dose is drawn into syringe?
By using small syringes (100 units or less)
Why is it important to eat after administering insulin?
to aviod hypoglycemia
When your patient is taking oral hypoglycemics and is scheduled for a diagnostic test that requires him/her to be NPO what should you do?
contact the physician for further orders
Monitoring of lab values for adverse effects
- To asess liver function
- May decrease serum levels of: Potassium, calcium and magnesium
Ingesting alcohol when receiving insulin can cause?
Why is insulin is administered parenterally?
Becuase the GI tract destroys insuline
What are the endocrine and exocrine functions of the pancreas?
- produces insuline and glucagon
- digestion; secretes pancreatic fluid w/ digestive enzymes
How do you treat diabetes insipidus?
With Vasopressin or desmopressin