What are the viruses that cause viral hemorrhagic fever?
What virus causing viral hemorrhagic fever has a positive sense?
What are the common symptoms to all viral hemorrhagic fevers?
fever, myalgia, thrombocytopenia, and proteinuria
How long is the incubation period of viral hemorrhagic fever?
What inflammatory mediators are responsible for the late symptoms of viral hemorrhagic fever?
What inflammatory mediators are responsible for the sudden onset symptoms of viral hemorrhagic fever?
TNF-α, IL-6, viral proteins
How does IFN-α contribute to the immunological response to viral hemorrhagic fevers?
activates the synthesis of anti-viral proteins
Tx for viral hemorrhagic fever includes antipyretics, analgesics, and fluid management. What analgesic is c/i?
What do you look for when analyzing pre-immune and immune serum in pts suspected with viral hemorrhagic fever?
development of antibodies
What are the clinical labratory tests used in the dx of viral hemorrhagic fevers?
Why would humoral immunity be activated in a viral infection?
neutralizing antibodies that help recruit and activate complement
Because viral hemorrhagic fevers can cause shock and hypotension, what is important to its management?
careful fluid management
What is the vector of the flavivirus?
What are the fevers caused by flavivirus?
yellow and dengue
What symptom is textbook for yellow fever?
What areas of the world have yellow fever?
South America and Eastern, Central, Western Africa
What areas of the world have dengue?
Tropical and Sub-Tropical Regions throughout the world (including Asia)
What symptoms are unique to dengue among the viral hemorrhagic fevers?
bone pain, congestion of conjunctiva
What viral hemorrhagic fever is a filamentous virus?
What are the species of the filovirus?
Ebola and Marburg
How is filovirus transmitted?
direct contact with bodily fluids, aerosols
What is the reservoir for the filovirus?
What fevers come from the bunyavirus?
Rift Valley fever, Crimean-Congo HF, hantavirus
What is the reservoir for the rift valley virus?
sheep and cattle
Where in the world do is rift valley fever seen?
most of Africa
(except some countries in the north)
Where in the world do is crimean-congo hemorrhagic fever seen?
parts of Africa
Which virus causing hemorrhagic fever can cause renal symptoms?
What fevers come from the arenavirus?
Lassa, Junin, Machupo, Whitewater Arroyo
How is the arenavirus transmitted?
What is the reservoir for the arenavirus?
Where is the "Old World" arenavirus found?