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Causative Disease Ehrlichia spp. & Anaplasma phagocytophilum Ehrlichia chaffeensis causes Human Monocytic Enrlichiosis HME Human Monocytic Enrlichiosis Ehrlichia ewingii Pathogen of dogs. causes a granulocytic disease Anaplasma phagocytophilum causes Human Granulocytic Anaplasmosis HGA Human Granulocytic Anaplasmosis Transmission tick borne Distribution for Human Monocytic Enrlichiosis widely distributed in U.S. esp. SE States - few records in Europe, Asia & N. Africa Vector for Human Monocytic Enrlichiosis Amblyomma americanum Amblyomma americanum is the lone star tick Reservoir host for Human Monocytic Enrlichiosis white-tailed deer 1st epidemiological study for Human Monocytic Enrlichiosis Brunswick, GA (1988) Early symptoms of Human Monocytic Enrlichiosis flu-like illness - fever, chills, headache, muscle aches Late symptoms of HME vomiting, cough, abdominal pain, lymphadenopathy, rash, confusion Serious symptoms of HME renal failure, vascular coagulation, seizures, coma Leukocytopenia Low white blood cells count Thrombocytopenia Low blood platelet count Distribution of Human Granulocytic Anaplasmosis N. America & Europe Vectors of Human Granulocytic Anaplasmosis Ixodes scapularis - blacklegged tick/deer tick (Eastern USA) , Ixodes pacificus - western blacklegged tick (Western USA) , Ixodes ricinus - sheep tick/ castor bean tick (Europe) Reservoir hosts for HGA Peromyscus spp. - white-footed mouse / cotton mouse, Neotoma spp. - woodrats HGA treatment doxycycline