Pharmacotherapy Exam III - CKD Ward
About this set
Created by:
momma_mindy on December 4, 2011
Subjects:
Description:
Dr. Ward's CKD lecture
Log in to favorite or report as inappropriate.
Order by
20 terms
Terms | Definitions |
|---|---|
 What are the nonpharmalogic treatments of CKD | Protein restriction |
| What did the DCCT study show for the pharmacologic treatment of diabetic patients with CKD | DCCT study showed benefits of intensive insulin therapy on kidney and other diabetes outcomes |
| What is intensive insulin therapy (IIT) | insulin administered 3 or more times daily or use of pump to attain blood glucosse levels of 70-120 mg/dl preprandial and <180 mg/dl postprandial |
| BP goal for patients with CKD and HTN or DM | < 130/80 |
| BP goal for patients with CKD with HTN or DM and proteinuria | <125/75 |
| first line therapy for HTN in CKD patients | ACEI or ARB |
| The only ACEI that doesn't have reduced clearance in CKD | fosinopril |
| How do ACEIs and ARBs reduce proteinuria | by reducing intraglomerular pressure |
| susceptibility factors for CKD | age, race, income, education, systemic inflammation, dyslipdemia, low birth weight, low kidney mass |
| initiation factors | autoimmune disease, DM, drug toxicity, HTN, infections, obstructions, polycystic disease, urinary stones |
| progression factors | hyperglycemia, HTN, Obesity, Proteinuria, Smoking |
| Which factors directly result in kidney damage? | initiation factors |
| What is the key predictor of stage 5 ESRD | proteinuria |
| Blood glucose goal for CKD patients with DM | 90-130 mg/dL fasting and <180 mg/dL postprandial; and an A1C < 7% |
| key elements of the pathway to irreversible renal parencymal damage and ESRD | loss of nephron mass; glomerular capillary HTN; proteinuria |
| body's compensatory mechanism to maintain GFR to offset the loss of nephron mass due to exposure to initation risk factors | hypertrophy to maintain renal function |
| downside of compensatory renal hypertrophy | intraglomerular hypertension which results proteinuria (this damage causes inflammatory response too) |
| Who do you screen for CKD | screen pts that have DM, HTN, genitourinary abnormalities, older age, family history |
| symptoms of later stages of CKD | edema, cold intolerance, sob, palpitations, cramping and muscle pain, depression, anxiety, fatigue, sexual dysfuntion |
| primary and secondary goal of hyperlipidemia treatment | primary - reduce risk of cv disease; secondary - reduce proteinuria and renal function decline |
First Time Here?
Welcome to Quizlet, a fun, free place to study. Try these flashcards, find others to study, or make your own.