| Term | Definition |
| Abraham Lincoln | Republican candidate chosen President of the United States of America |
| Roger Taney | Chief Justice who ruled with the majority that slaves were property |
| Dred Scott | Slave who sued for his freedom |
| Henry Clay | Proposed the Missouri Compromise of 1820 |
| Stephen Douglas | Sponsor of the Kansas-Nebraska Act, 1854 |
| Jefferson Davis | Chosen as President of the Conferate States of America |
| secede | withdraw or leave |
| South Carolina | First state to leave the Union |
| Missouri Compromise | No slavery north of a line of latitude - 36 30" |
| Missouri Compromise | Maine entered the Union as a free state |
| Missouri Compromise | Missouri entered the Union as a slave state |
| Missouri Compromise | Slave and free states remained equal in number of Senators |
| Compromise of 1850 | California entered as a free state |
| Compromise of 1850 | Banned slave trade in Washington, D.C. |
| Compromise of 1850 | Congress passes a stronger Fugitive Slave law |
| Kansas-Nebraska Act | Replaced the Missouri Compromise in the Lousiana Territory |
| Kansas-Nebraska Act | Caused fighting between pro and anit slavery forces in this territory |