Newer AED; no p450 metabolism
Newer AED; She better not get drowsy, weak muscles or psychotic on the farm, but she can take her birth control and it will still work.
Newer AED; No p450 metabolism, controlled because it causes euphoria and dependence. Sleepiness, dizziness, rhabdomyolysis
seizure, dizzy, your bicarb may go down (met acidosis) and not able to sweat. Don't take phenytoin to try to help, because it will be toxic, and get your eyes checked after to make sure you don't have glaucoma
Newer AED: Don't take with on phenytoin or carbamazepine because it won't work.
hot without sweating and losing bicarb. But it's outside - a sulfonamide - and you might get stones
causes your bones to stop producing blood cells (aplastic anemia) and your liver to fail.
Somnolence, nystagmus, tremor, vomiting and headache and may cause heart problems - shorten your QT, or cause multiorgan sensitivity.
Newer AED; visual problems. Black Box.
Newer AED; people who wear lacoste may have PR problems and dysrhythmias
Newer AED; for lennox gasto. Tired, UTI, aggression, insomnia, dysarthria, constipation
Atypical antidepressant and 3rd line treatment for ADHD; NE and DA. Seizure risk, weight loss, blurred vision
Centrally Acting Alpha2 agonists
2nd line ADHD treatment; stimulates alpha2 receptors, how this helps is unknown. Hypotension, dry mouth, constipation, syncope and bradycardia
2nd line ADHD. Nonstimulant, max effect in a few weeks, reduced apetite, syncope, liver injury, orthostatic hypotension.
Insomnia; tolerance develops to main effects but not to respiratory depression. Lipid soluble.
Atypical Antidepressant or Sedative; Trazodone like nefazodone is alpha 1 alpha up - priapism, edema, HTN, MI, QT prolongation. Serotonin too, but very sedating.
TCA used for insomnia
Used for insomnia. Anticholinergic effects
Quick to start and fast acting, but they make the patient slow. Lose testosterone and increase prolactin.
Anxiolytic; no CNS depression! Though you'll get to noanxietyland more slowly. You may also get dizzy, light headed, nauseous, a headache, a little nervous, or the full out serotonin syndrome. No grapefruits.
Gastric lavage, activated charcoal, dialysis, monitor RR & BP, Flumazenil
Atypical antidepressant. Hepatotoxicity, dysrhythmias, priapism. 5HT and Alpha1 (alpha males might get priapism).
incr 5HT and NE, blocks alpha TWO and 5HT receptors. Tetracyclic. Agranulocytosis and neutropenia, torsades, edema, incr LFTs and cholesterol.
Antidepressant. Contraindicated in pts with severe renal or hepatic impairment.
SNRI. Contraindicated in hepatic disease. Increases blood pressure, mydriasis, MAOI's contraindicated.
SNRI. Reduce dose in renal or hepatic impairment, MAOIs contraindicated, mydriasis, dysrhythmias, nausea common.
Antidepressants. MAOIs contraindicated, serotonin syndrome, insomnia, GI, weight gain...
SSRI; QT prolongation
Antidepressants. 8x avg dose is lethal. Hypotension - anticholinergic; diaphoresis, seizures; Variable half lives.
Antiepileptics for Bipolar Tx
Valproic acid (50-125), Carbamazapine (4-12), Lamotrigine.
Target level 0.8-1.2 or 0.6-1.2 (know dif). Anything kidney or thyroid related, also dysrhythmias.
Atypical antipsychotic causes Agranulocytosis (CBCQ1W!), Bound to plasma proteins. Seizure risk.
1st gen antipsychotic. QT prolongation.
1st gen antipsychotic. QT prolongation and seizure
Opioid antagonist. BB Hepatotoxicity. Prevent relapse after detox.
Naloxone. Reversal of opioid OD.
Central Opioid Agonist; mu receptors and block NE reuptake. Don't take with CNS depressants or anti-depressants.
Central Opioid Agonist; mu receptors and blocks NE/5HT uptake. Don't take with CNS depressants, anti-depressants.
Pain med. BB Hepatotoxicity. 1g/dose, 4g/day. Overdose=hepatic necrosis. Use Acetylcysteine which restores glutathione
selective to cox 2, but still get some abdominal pain, dyspepsia, renal toxicity. Sulfonamide. cardio risk too since no antiplatelet action. Special DI is warfarin - increases warfarin's anticoagulant effects.
Analgesic/Antipyretic. risk of Reye's. BB - bleeding/perforation and Cardio event; drowsiness, dizziness, blurred vision, kidney damage (not selective!)
Analgesic. Do not use with children that have chickenpox or flu symptoms - may lead to hypersensitivity Reye's Syndrome. Also no alcohol, glucocorticoids, ACE/ARB or lithium (lithium will go up).
Partial and Gen TC seizures. nausea, vomiting, headache, dizziness, diplopia, and a life-threatening rash.
like carbamazepine. ABCDs (but no blood issues), also dizziness and drowsiness, so DI's include diuretics and CNS depressants
in prison you are neuropsychologically depressed, and too much can make you stop breathing. (the only GABA one). Intermittant porphyria (phenobarb, phyria) - hemoglobin abnormality.
50-100; think acid - affects your GI tract, eat more and liver gets hurt (hyperammonemia?), pancreas, gain weight, feel tired. And blood dyscrasias.
4-12, inducer and autoinducer, PTC. Crazy eyes, bone marrow, ADH Derm. ABCD - A:too much ADH →hypoosomolarity; B - bone marrow, blood dyscrasias and birth defects; C - crazy eyes (visual disturbance, nystagmus, ataxia); D - dermatologic, photosensitivity and rash.
10-20, variable half life, Michaelis-Mentin, partial and TC (PTC). Crazy eyes, crazy teeth and crazy hair, skin, bone. Hepatotoxicity and blood dyscrasias too. Too much: toxic, too little: breakthrough seizures.