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5 Written questions

5 Matching questions

  1. What does transferase do?
  2. What role does UDP-glucose play in Glycogen synthesis?
  3. What irreversible reaction drives the synthesis of UDP-glucose?
  4. What is Uridine Diphosphate?
  5. What is debranching?
  1. a Uridine diphosphate is a nucleotide composed of uracil, ribose and pyrophosphate
  2. b Glycogen synthesis involves transfer of glucose from UDP-glucose to a growing chain
  3. c PPi+ H2O=> 2Pi
  4. d When glucose residues are removed to the "limit dextran" which is the 4th glucose residue from the branch glucose
  5. e Transferase transfers the 3 terminal glucose residues from outer branch to the center, main linear branch

5 Multiple choice questions

  1. A very large, branched polymer of glucose residues. Most of the glucose residues are linked by alpha 1,4 glycosidic bonds. branches about every 10th residue are linked by alpha 1,6 glycosidic bonds
  2. Must be at least 4 residues away from other branches. Links are alpha 1,6 glycosidic bond
  3. Glycogen (n residues) + Pi=> glucose-1-phosphate + Glycogen (n-1 residues)
  4. Utilizes a non branched string of at least 11 glycosyl residues long. Branching enzyme transfers a string of typically 7 residues from non reducing end to presumptive branch point.
  5. Increases the number of terminal glucose residues which are site of action for glycogen phosphorylase and synthase. Branching increases rate of glycogen synthesis and degradation

5 True/False questions

  1. What is glycogenin?Glycogenin is both an enzyme and its substrate consisting of two 37 kD subunits. Each subunit catalyzes addition of a glycosyl unit from UDP glucose to Tyr 194 of other subunit. Subsequently, 7 more glycosyl units are added so that 8 glycosyl units are attached to Tyr 194 for each subunit

          

  2. What is phosphoglucomutase?Phosphoglucomutase is a phospho enzyme and converts Glucose 1 phosphate to glucose 6 phosphate for further metabolism

          

  3. What are the properties of Glycogen synthase?Utilizes a non branched string of at least 11 glycosyl residues long. Branching enzyme transfers a string of typically 7 residues from non reducing end to presumptive branch point.

          

  4. What enzyme catalyzes the transfer of glucose from UDP-glucose to a growing chain?Glucose-1-phosphate +UTP =>UDP-glucose + PPi

          

  5. What does alpha 1,6 glucosidase do?Phosphoglucomutase is a phospho enzyme and converts Glucose 1 phosphate to glucose 6 phosphate for further metabolism

          

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