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5 Written Questions

5 Matching Questions

  1. What role does UDP-glucose play in Glycogen synthesis?
  2. What enzyme catalyzes the transfer of glucose from UDP-glucose to a growing chain?
  3. What is glycogenin?
  4. What is debranching?
  5. What is phosphoglucomutase?
  1. a Glycogen synthase catalyzes transfer of glucose from UDP-glucose to a growing chain
  2. b Glycogenin is both an enzyme and its substrate consisting of two 37 kD subunits. Each subunit catalyzes addition of a glycosyl unit from UDP glucose to Tyr 194 of other subunit. Subsequently, 7 more glycosyl units are added so that 8 glycosyl units are attached to Tyr 194 for each subunit
  3. c Glycogen synthesis involves transfer of glucose from UDP-glucose to a growing chain
  4. d Phosphoglucomutase is a phospho enzyme and converts Glucose 1 phosphate to glucose 6 phosphate for further metabolism
  5. e When glucose residues are removed to the "limit dextran" which is the 4th glucose residue from the branch glucose

5 Multiple Choice Questions

  1. Transferase transfers the 3 terminal glucose residues from outer branch to the center, main linear branch
  2. Glycogen phosphorylase, Transferase, alpha 1,6 glucosidase, phosphoglucomutase
  3. Alpha 1,6 glucosiase hydrolyzes the alpha 1,6 glucosidic bond to release a free glucose molecule
  4. Increases the number of terminal glucose residues which are site of action for glycogen phosphorylase and synthase. Branching increases rate of glycogen synthesis and degradation
  5. A glycosyl unit from UDP glucose is transferred to the hydroxyl group at the C4 of the terminal glucose residue forming a alpha 1,4 glycosidic bond. Requires a glycogen molecule that is a minimum of 4 residues to which a glycosyl will be added

5 True/False Questions

  1. What converts Glucose 6 phosphate into glucose in liver?Glucose 6 phosphatase converts Glucose 6 phosphate into glucose for export out of the liver and transport to other tissues

          

  2. What is the overall reaction of glycogen phosphorylase activity?Glycogen (n residues) + Pi=> glucose-1-phosphate + Glycogen (n-1 residues)

          

  3. What is the limit dextran?Glycogenin is both an enzyme and its substrate consisting of two 37 kD subunits. Each subunit catalyzes addition of a glycosyl unit from UDP glucose to Tyr 194 of other subunit. Subsequently, 7 more glycosyl units are added so that 8 glycosyl units are attached to Tyr 194 for each subunit

          

  4. What irreversible reaction drives the synthesis of UDP-glucose?PPi+ H2O=> 2Pi

          

  5. What is glycogen?Glycogenin is both an enzyme and its substrate consisting of two 37 kD subunits. Each subunit catalyzes addition of a glycosyl unit from UDP glucose to Tyr 194 of other subunit. Subsequently, 7 more glycosyl units are added so that 8 glycosyl units are attached to Tyr 194 for each subunit

          

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