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5 Written questions

5 Matching questions

  1. What are the properties of Glycogen synthase?
  2. Why is branching important in glycogen synthesis?
  3. What are the properties of the presumptive branch point?
  4. What is glycogenin?
  5. What is the limit dextran?
  1. a Glycogenin is both an enzyme and its substrate consisting of two 37 kD subunits. Each subunit catalyzes addition of a glycosyl unit from UDP glucose to Tyr 194 of other subunit. Subsequently, 7 more glycosyl units are added so that 8 glycosyl units are attached to Tyr 194 for each subunit
  2. b Must be at least 4 residues away from other branches. Links are alpha 1,6 glycosidic bond
  3. c Increases the number of terminal glucose residues which are site of action for glycogen phosphorylase and synthase. Branching increases rate of glycogen synthesis and degradation
  4. d A glycosyl unit from UDP glucose is transferred to the hydroxyl group at the C4 of the terminal glucose residue forming a alpha 1,4 glycosidic bond. Requires a glycogen molecule that is a minimum of 4 residues to which a glycosyl will be added
  5. e The 4th glucose residue from the branch glucose

5 Multiple choice questions

  1. Glucose 6 phosphatase converts Glucose 6 phosphate into glucose for export out of the liver and transport to other tissues
  2. Transferase transfers the 3 terminal glucose residues from outer branch to the center, main linear branch
  3. Glycogen phosphorylase, Transferase, alpha 1,6 glucosidase, phosphoglucomutase
  4. When glucose residues are removed to the "limit dextran" which is the 4th glucose residue from the branch glucose
  5. Alpha 1,6 glucosiase hydrolyzes the alpha 1,6 glucosidic bond to release a free glucose molecule

5 True/False questions

  1. What is glycogen?Glycogenin is both an enzyme and its substrate consisting of two 37 kD subunits. Each subunit catalyzes addition of a glycosyl unit from UDP glucose to Tyr 194 of other subunit. Subsequently, 7 more glycosyl units are added so that 8 glycosyl units are attached to Tyr 194 for each subunit

          

  2. What enzyme catalyzes the transfer of glucose from UDP-glucose to a growing chain?Glycogen synthase catalyzes transfer of glucose from UDP-glucose to a growing chain

          

  3. What is Uridine Diphosphate?Uridine diphosphate is a nucleotide composed of uracil, ribose and pyrophosphate

          

  4. What is phosphoglucomutase?Phosphoglucomutase is a phospho enzyme and converts Glucose 1 phosphate to glucose 6 phosphate for further metabolism

          

  5. What irreversible reaction drives the synthesis of UDP-glucose?PPi+ H2O=> 2Pi

          

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