how does crol dec fluidity? How does it inc fluidity?
dec by preventing fa chains from bending
inc by preventing fa chains from binding together
where is most crol synthesized?(1st and second)
liver and intestinal mucosa
where in the liver cell does crol synthesis occur?
how many c in crol?
which enzyme is regulated in crol synthesis?
HMG CoA reductase
what transcription factor upregulates crol synth? What down regulates this?
sterols and non-sterol isoprenoids
how does crol inhibit SREBP production?
it is made as a membrane boud ptn that gets cleaved to enter nucleus. crol prevents its cleavage
Which crol intermediate is important to make a whole lotta other stuff?
activated isoprene, farnesyl pyrophosphate
what are some other isoprenoids important to biochem
vit A, E, K
what is the purpose of apoproteins found on lipopoteins?
to bring apolipoptns into tissues
where do chylomicrons go? What do they become via what enzyme
what is apB-100 ?
found on LDL
receptor mediated endocytosis
receptor mediated endocytosis has what affect on crol synth? How
1. turns down transcription of hmg coa reductase
2. turns off expression of LDL receptor ptn
where is LCAT found?
whats iff btwn bile acids and bile salts?
Salts have aa, acids dont
are bile salts more or less hphillic than crol?
how do Salts have aa, acids dont
bind to it and prevent its absorption
what is Familial Hypercholesterolemia
a problem with LDL receptors, so no LDL is brought into liver so no HMG coa Reductase inhibition
how is Familial Hypercholesterolemia fixed?