(test 4)Cholesterol
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19 terms
Terms | Definitions |
|---|---|
 how does crol dec fluidity? How does it inc fluidity? | dec by preventing fa chains from bending inc by preventing fa chains from binding together |
| where is most crol synthesized?(1st and second) | liver and intestinal mucosa |
| where in the liver cell does crol synthesis occur? | cytosol |
| how many c in crol? | 27 |
| which enzyme is regulated in crol synthesis? | HMG CoA reductase |
| what transcription factor upregulates crol synth? What down regulates this? | SREBP sterols and non-sterol isoprenoids |
| how does crol inhibit SREBP production? | it is made as a membrane boud ptn that gets cleaved to enter nucleus. crol prevents its cleavage |
| Which crol intermediate is important to make a whole lotta other stuff? | activated isoprene, farnesyl pyrophosphate |
| what are some other isoprenoids important to biochem | vit A, E, K |
| what is the purpose of apoproteins found on lipopoteins? | to bring apolipoptns into tissues |
| where do chylomicrons go? What do they become via what enzyme | adipose tissue chylomicron remnants LPL |
| what is apB-100 ? | found on LDL receptor mediated endocytosis |
| receptor mediated endocytosis has what affect on crol synth? How | turns off 1. turns down transcription of hmg coa reductase 2. turns off expression of LDL receptor ptn |
| where is LCAT found? | HDL |
| whats iff btwn bile acids and bile salts? | Salts have aa, acids dont |
| are bile salts more or less hphillic than crol? | more hphillic |
| how do Salts have aa, acids dont lower crol? | bind to it and prevent its absorption |
| what is Familial Hypercholesterolemia | a problem with LDL receptors, so no LDL is brought into liver so no HMG coa Reductase inhibition |
| how is Familial Hypercholesterolemia fixed? | liver transplant |
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