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Osteogenic (or progenic) Cell primitive stem cell; 1 unspecialized cells derived from mesenchyme; present in the periosteum and the endosteum; can undergo mitosis and develop into osteoblasts Osteoblasts matrix-synthesizing cell; 2 responsible for bone growth; main bone-building cells; secrete collagen fibers and other organic components needed to build bones; no mitotic activity; finally, are trapped by own matrix and become osteocytes Osteocytes mature bone cell; 3 maintains bone matrix; principle cells of bone tissue; most abundant; no longer active in bone synthesis but remains metabolically active and also maintains the bone, such as its exchange of nutrients, waste, and calcium with the blood Osteoclasts bone-resorbing cell; 4 giant cells with 50 or more nuclei; derived from circulating monocytes (a type of white blood cell); functions in the destruction of bone matrix, which is important in development, growth, maintenance, and repair of bones