7 Written Questions

1. prolonged feelings of worthlessness and guilt. disruption of normal eating habits. sleep disturbances. general slowing of behavior.
2. gases pass easily (small uncharged molecules), active transport (amino acids, glucose, fats). NO large or electrically charged molecules
3. capillaries in the brain are not leaky--they have tight junctions & are covered with astrocyte feet. prevents materials from moving in and out easily.
4. response to a novel drug is reduced because of tolerance developed in response to a related drug. suggests common target.
5. substance that enhances the function of a synapse
6. most psychoactive drugs influence chemical reactions at synapses
7. broken down in kidneys, liver, intestines. excreted in urine, feces, sweat, breastmilk, & exhaled air.

6 Multiple Choice Questions

1. people learn to cope with being intoxicated
   1. cross tolerance
   2. metabolic tolerance
   3. learned tolerance
   4. cellular tolerance
2. substance that blocks the function of a synapse
   1. tolerance
   2. learned tolerance
   3. agonist
   4. antagonist
3. substance that acts to alter mood, thought, or behavior. can be used to manage neuropsychological illness.
   1. cross tolerance
   2. elimination of drugs
   3. psychoactive drug
   4. metabolic tolerance
4. increased # enzymes used to break down substance
   1. cellular tolerance
   2. cross tolerance
   3. learned tolerance
   4. metabolic tolerance
5. pre/postnatal growth retardation, esp of the brain. head circ below 10th percentile. CNS involvement- neuro abnormalities, developmental delay, intellectual impairment. facial abnormalities. CAUSE: overactivation of GABA receptors during development
   1. learned tolerance
   2. cellular tolerance
   3. fetal alcohol syndrome
   4. metabolic tolerance
6. decrease in response to a drug with passage of time
   1. tolerance
   2. cellular tolerance
   3. cross tolerance
   4. learned tolerance

6 True/False Questions

1. indirect sensitization → block receptor sites by mimicing neurotransmitter but not performing the function of it

   True        False

2. cellular tolerance → people learn to cope with being intoxicated

   True        False

3. barrier-free brain sites → pineal gland, pituitary gland, area postrema

   True        False

4. drug sensitization → block receptor sites by mimicing neurotransmitter but not performing the function of it

   True        False

5. endothelial cells → decrease in response to a drug with passage of time

   True        False

6. direct sensitization → increased amount of neurotransmitter available, higher production & lower reuptake

   True        False