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Which type of collagen is most frequently found in cartilage?
1. type I
2. type II
3. type III
4. type IV
5. type V

2. type II

Which type of collagen is most frequently found in the basal lamina of epithelial and endothelial cells?
1. type I
2. type II
3. type III
4. type IV
5. type V

4. type IV

Which of the following intracellular and extracellular events is the FIRST to occur in the formation of a collagen fibril?
1. procollagen triple-helix formation
2. secretion of procollagen in a secretory vesicle
3. cleavage of propeptides
4. self assembly of three pro-alpha chains
5. hydroxylation of selected prolines

5. hydroxylation of selected prolines

Which of the following statements concerning collagen is INCORRECT?
1. collagen has a trihelical structure
2. the molecular weight of collagen is above 100,000
3. hydroxyproline is incorporated into the molecule by tRNA
4. destruction of collagen can be caused by collagenases
5. collagen contains both hydroxyproline and hydroxylysine residues

3. hydroxyproline is incorporated into the molecule by tRNA

Which of the following characteristics most readily distinguishes Amelogenesis imperfecta from Dentinogenesis imperfecta?
1. radiographic appearance
2. hereditary background
3. presence of blue sclera
4. color of teeth
5. associated hair loss

1. radiographic appearance

The amino acid composition of collagen (Type I) is characterized by the presence of:
a. cysteine
b. hydroxyproline and hydroxylysine
c. no sulfur containing amino acids
d. glycine as almost one third of all residues
e. a high content of aromatic amino acids
1. a, b and d
2. a, c and e
3. b only
4. b, c and d
5. b and d only

4. b, c and d

Type -I collagen is composed of:
1. two alpha 1 chains only
2. three alpha 2 chains
3. one alpha 1 and two alpha 2 chains
4. two alpha 1 and one akpha2 chain
5. three alpha 1 chains
6. two alpha2 chains only

4. two alpha 1 and one akpha2 chain

The alpha helix is:
1. a feature of the tropocollagen molecule
2. formed by covalent bonds between adjacent polypeptide chains
3. generated by the oxidation of cysteine residues to form disulfide bonds
4. the normal structure of tRNA
5. none of the above

5. none of the above

Which of the following statements regarding tropocollagen structure are CORRECT?
a. tropocollagen is stabilized by disulfide crosslinks
b. in tropocollagen the polypeptide chains are coiled into alpha helices
c. tropocollagen has a high content of glycine and hydroxylysine
d. the tropocollagen is an inextensible rodlike molecule
e. the elasticity of tropocollagen is due to the hydrogen-bonding
f. proline and hydroxyproline constitute some 20% of tropocollagen amino acids
1. a, d and f
2. b and f only
3. e, c and f
4. c and d only
5. d and f only

5. d and f only

The alpha helix is a feature of:
1. protein tertiary structure
2. collagen
3. a beta pleated sheet
4. DNA
5. Protein secondary structure

5. Protein secondary structure

A 4-year-old child has normally shaped grayish colored teeth that exhibit extensive wear. Radiographic examination shows a normal complement of teeth but extensive deposits of secondary dentin have almost obliterated pulp chambers and canals. The most probable diagnosis is:
1. tetralogy of Fallot
2. tetracycline staining
3. amelogenesis imperfecta
4. cleidocranial dysostosis
5. dentinogenesis imperfecta

5. dentinogenesis imperfecta

A patient with dentinogenesis imperfecta has a history of multiple fractures. Examination reveals blue sclera. The most probable diagnosis is:
1. achondroplasisa
2. Marfan's syndrome
3. osteogenesis imperfecta
4. Albers-Schonberg disease

3. osteogenesis imperfecta

Which type of Osteogenesis Imperfecta is a lethal, perinatal disease?
1. type I
2. type II
3. type III
4. type IV
5. none of the above

3. type III

Most heritable diseases involving structural proteins such as collagen are transmitted by which of the following traits?
1. Sex-linked recessive
2. Sex-linked dominant
3. Autosomal recessive
4. Autosomal dominant
5. Polygenic

4. Autosomal dominant

Which ONE of the following statements is CORRECT?
As collagenous bone tissue matures, the collagen becomes chemically cross-linked:
1. With pyrophosphate links
2. By the condensation of oxidized lysine side chains
3. Through the formation of beta-glycosidic linkages
4. By the formation of beta turns associated with proline residues
5. Through the condensation of hydroxyproline

2. By the condensation of oxidized lysine side chains

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