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5 Written questions

5 Matching questions

  1. Tetracycline
  2. Chlamydia
  3. Aminoglycoside
  4. Key concept
  5. broad-spectrum antibiotics
  1. a The type of antibiotics that are more likely to cause superinfections.
  2. b Prototype drug: tetracycline HCL (Achromycin, others)
    Mechanism of action: effective against broad range of gram-positive and -negative organisms
    Primary use: chlamydiae, rickettsiae, and mycoplasma
    Adverse effects: superinfections, nausea, vomiting, epigastric burning, diarrhea, discoloration of teeth, photosensitivity
  3. c Anti-infective drugs are classified by their chemical structures (e.g., aminoglycoside, fluoroquinolone) or by their mechanism of action (e.g., cell-wall inhibitor, folic acid inhibitor).
  4. d Prototype drug: gentamicin (Garamycin)
    Mechanism of action: to act as broad-spectrum, bacteriocidal antibiotic
    Primary use: for serious urinary, respiratory, nervous, or GI infections
    -Often used in combination with other antibiotics
    -Used parenterally or as drops (Genoptic) for eye infections
    Adverse effects: ototoxicity and nephrotoxicity
  5. e Veneral disease, endometriosis

5 Multiple choice questions

  1. The aminoglycosides are narrow-spectrum drugs, most commonly prescribed for infections by aerobic, gram-negative bacteria. They have the potential to cause serious adverse effects such as ototoxicity, nephrotoxicity, and neuromuscular blockade.
  2. The small pieces of circular DNA that are transferred through conjugation, which is passing on the resistance gene to other bacteria.
  3. An organism that can cause disease.
  4. Errors during replication of bacterial DNA and Overuse of antibiotics
  5. Pharyngitis, pneumonia, skin infections, speticemia, endocarditis

5 True/False questions

  1. Key conceptThe macrolides are safe alternatives to penicillin. They are effective against most gram-postive bacteria and many gram-negative species.

          

  2. Aminoglycoside•Narrow-spectrum drugs, bacteriocidal
    •Reserved for serious systemic infections caused by aerobic gram-negative bacteria
    -E. coli, serratia, proteus, klebsiella, and pseudomonas
    •Inhibit bacterial protein synthesis
    •More toxic than most antibiotics
    •Have potential to cause serious adverse effects
    -Ototoxicity, nephrotoxicity, neuromuscular blockade
    •Note difference in spelling "mycin" and "micin"—reflects origins of drug

          

  3. gram-negativeBacteria that contain a thick cell wall and retain a purple color after staining. Staphylococci, streptococci, and enterococci.

          

  4. culture and sensitivity testingThe process of growing out the pathogen and identifying the most effective antibiotic.

          

  5. Wide spectrumRocky Mountain spotted fever

          

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