| Term | Definition |
|---|
| facultative | Salmonella are ________ intracellular pathogens |
| flagellar | H is the ______ antigen |
| somatic | O is the ______ antigen |
| capsular | K is the ______ antigen |
| Vi | capsular antigen that is possessed by Salmonella that cause Typhoid fever |
| serovar | strain differentiated by serological means |
| serotype | antigenic property of a cell or virus identified by serological methods |
| biovar | strains that are differentiated by biochemical or other non-serological means |
| pathogenicity islands | large regions of DNA that encode clusters of genes associated with virulence |
| SPI1 | pathogenicity island - causes membranes to ruffle, allows invasion |
| SPI2 | pathogenicity island - avoids lysosomal fusion, allow bacteria to multiply |
| sensitive | Salmonella are acid _____ (sensitive, resistant) |
| Typhoid fever | serious and often-fatal disease characterized by nausea, vomiting and fever |
| humans | S. typhi is only pathogenic to |
| S. typhi | main source of infection for _____ is contaminated water or consumption of food washed or irrigated with contaminated water |
| gall bladder | S. typhi can persist in the ____ ______ and be shed in the feces for years |
| systemic | S. typhi can multiply in the spleen and liver, and large numbers of bacteria are released into the blood causing a _____ infection |
| gastroenteritis | S. typhimurium causes self-limiting _________ in humans |
| Typhoid fever | S. typhimurium causes _____ ______ in mice |
| systemic shock | S. typhimurium may cause _____ _____ in immunocompromised or elderly people |
| infection | food _____ - pathogen has had time to replicate in the intestine |
| poisoning | food _____ - results from ingestion of food that is contaminated with preformed toxins |
| M | _ cells are specialized cells of intestinal tract that have the function of sampling antigens from the lumen of the intestine |
| prostaglandin | ______ produced by neutrophils acts on the intestinal epithelial cell increases the internal concentration of cAMP |
| not | it is ____ (well / not ) known how bacteria escape from host cell to infect other cells |
| gastric acid | the first host defense against Salmonella infection |
| serovars | typhi and typhimurium are different _____ |
| SPI1 | pathogenicity island - triggers actin rearrangements, allowing bacterium to invade the cell. |
| ruffling | membrane ______ - pseudopods extend and engulf bacterium to bring it in an endosome |
| SPI2 | pathogenicity island - inject proteins into membrane of endosome so it no longer binds to lysosomes |
Combine with other sets
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