HD2 Drugs: Parkinsonism
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14 terms
Terms | Definitions |
|---|---|
 Levodopa | Dopamine (DA) precursor, metabolized to DA in brain (and, unfortunately, peripherally as well) |
| Carbidopa | Blocks peripheral metabolism of levodopa to DA, allowing more levodopa to enter brain |
| Levodopa+Carbidopa = Sinemet | 2-drug combination for DA replacement therapy (see above) |
| Tolcapone | COMT inhibitor. Blocks peripheral metabolism of levodopa to an inactive metabolite; Liver-Tx |
| Entacapone | COMT inhibitor. Blocks peripheral metabolism of levodopa to an inactive metabolite. |
| Levodopa+Carbidopa+Entacapone = Stalevo | 3-drug combination for DA replacement therapy (see above) |
| Trihexyphenidyl | anticholinergic drug (inhibits motion-suppressing neurons) useful in early stage PD and for tremors |
| Bromocriptine | DA D2 receptor agonist, ergoline class (fibrosis side effect) |
| Pramipexole | DA D3>D2 agonist, non-ergoline class (no fibrosis), also used for RLS -- just like below |
| Ropinirole | DA D3>D2 agonist, non-ergoline class (no fibrosis), also used for RLS -- just like above |
| Amantadine | Enhances DA release from remaining undegenerated Substantia Nigra afferents, and blocks GLU. |
| Selegiline | MAO-B inhibitor of brain DA's metabolism to DOPAC. Antidepressant interaction (serotonin syndrome) |
| Rasagiline | MAO-B and MAO-A inhibitor of brain DA's metabolism to DOPAC; antidepressant and tyramine risk |
| Apomorphine | Powerful DA D1/D2 agonist used for emergency "OFF"-State rescue of immoblie PD patient |
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