| Term | Definition |
|---|
| ER is the most extensive membrane system in a | cell |
| ER serves as the what for other proteins going to other organelles including the ER itself | entry point |
| Once in ER, they are transported to other organelles via | transport vesicles |
| All proteins have a | ER signal sequence |
| most proteins enter ER as they are being | translated |
| the ribsome making the protein binds to the | Rough Endoplasmic Reticulum |
| What two components aid the guide of soluble proteins destined for the ER | SRP (Signal Recognition Particles) and SRP Receptors |
| SRP (Signal Recognition Particles) | Bind to the ER signal sequence on the protein as soon as it comes off the ribosome |
| SRP receptor | embedded into the ER membrane and recognizes the SRP |
| Binding of SRP to the ER signal on protein slows down | translation until the ribosome and the bound SRP find the SRP receptor |
| After the complex binds to the SRP receptor | SRP is realeased and translation resumes |
| As the protein is made, its threaded into the lumen of the ER through a | translocation channel in the ER membrane |
| the ER signal sequence remains bound to the | translocation channel |
| the rest of the protein threads through as a | large loop |
| Signal Peptidase | cleaves off the ER signal and the rest of the protein is released into the lumen of the ER |
| the channel opens and releases the | ER signal |
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