Secretory Pathway (Outward)
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14 terms
Danish | English |
|---|---|
| What is secretory pathway |  vesicular transport that extends to the plasma membrane |
| What is the side pathway | ER --> Golgi -->late endosome--> lysosome |
| main pathway, side branch | ER --> Golgi --> Cell Surface |
| Exocytosis | process by which most secreted molecules are exported from eukaryotic cell |
| Pathway of Exocytosis | ER --> Golgi --> Plasma Membrane |
| Most proteins moving along this pathway are chemically modified by | disulfide bonds |
| Many proteins that enter the lumen of the ER are | Glycosylated |
| Glycosylation | covalent attachment of oligosaccharide oxide chains |
| How does Glycosylation take place | N-Linked Glycosylation |
| What happens with N-Linked Glycosylationa preferred branched oligosaccharide (14 sugars) atteched to dolichol (hydrophobic molecule in membrane). It is then transformed to proteins in the lu | a preferred branched oligosaccharide (14 sugars) atteched to dolichol (hydrophobic molecule in membrane). They are then transformed to proteins in the lumen of the ER. Then attached to amino group of asparagine side chain |
| ER Retention of Proteins: What is the ER retention signal and where is it located? | KDEL and it is located at the C-Terminus |
| Exit of Proteins from the ER is highly | selective |
| If proteins are not correctly folded, then they can't | they can't exit from the Endoplasmic Reticulum (ER) |
| Chaperons | helps proteins fold properly so they can exit the ER |
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