Antibacterials: Protein Synthesis Inhibitors

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Aminoglycosides - MOA

inhibit IF2-30S

Aminoglycosides - Use

Gram negative

Aminoglycosides - Side Effects

ototoxicity, nephrotoxicity, neurotoxicity (presynaptic Ca influx)

Aminoglycosides (GNATS)

Gentamicin (neuropathy), Neomycin = topical (NH4 bacteria), Amikacin (hepatic excretion), Tobramycin (CF), Streptomycin = TB, Tularemia

Tetracyclines - MOA

block tRNA (30S)

Tetracyclines - Use

Gram positive, simple Gram negative, Atypicals, Rickettsia

Tetracyclines - Side Effects

photosensitivity (SPF15), errosive esophagitis, binds Calcium (no tums/milk), permanent grey teeth, P450 inducer, Fanconi's (old), negates OCP, not used with anuric pacients (produces nitrogen and increased BUN = Doxycycline is exception)

Tetracyclines

Minocycline = acne, Doxycycline (hepatic excretion), Demecocycline (blocks ADHr), Oxytetracycline

Chloramphenicol - MOA

block peptidyl tranferase (50S)

Chloramphenicol - Use

Gram positive, Rickettsia, Thyphoid Fever, HiB meningitis

Chloramphenicol - Side Effects

aplastic anemia, inhibits E.T.C 4, grey baby syndrome

Macrolides - MOA

block translocation (50S)

Macrolides - Use

Gram positive, simple Gram negative, atypicals

Macrolides - Side Effects

inhibit P450, Torsade with 3rd gen anti-histamines

Macrolides (ACE Me)

Azithromycin (pregos; longest t1/2; MAI = AIDS) Clarithromycin (dysguisia), Erythromycin (Penicillin allergy, Legionella; GI upset)

Lincosamides = Clindamycin - MOA

block translocation (50S)

Lincosamides = Clindamycin - Use

Gram positive, simple Gram negative, Anaerobes

Lincosamides = Clindamycin - Side Effects

Pseudomembranous colitis

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