| Term | Definition |
|---|
| 3 main strategies pathogens use to evade the immune system | 1.Viruses synthesize proteins 2. Infect cells that are designed to destroy them (cd4 Tcells) 3. Viruses undergo latency 4. Mutation and recombination |
| Viral Protein inhibition strategies | 1. inhibit host cytokine production 2. viral peptide transport of TAP 3. MHC I expression 4. complement activation |
| Viral latency | 1. virus enters cell but does not replicate 2. no viral replication or protein synthesis, therefore no T cell presentation 3. virus infects neurons |
| Herpes Strategies | 1. inhibits class I synthesis/transport 2. inhibits TAP 3. viral encoded Fc receptor 4. inhibits adhesion of lymphocytes to virally infected cells 5. synthesizes protein that inhibits C3 6. undergoes latency |
| Herpes simplex I | infects the trigeminal ganglion in the brain and then undergoes latency before full recovery |
| Epstein-Barr virus | infects B cells, Ag is presented to T cells. Most B cells are killed by CD8 cells, but some become latently infected. In addition, the virus inhibits proteasomes |
| Herpes Viruses | 1. Simpex I 2. Simplex II 3. Epstein-Barr 4. varicella zoster (chicken pox) |
| varicella zoster | After infection, undergoes latency and can re-infect. The re-infection is referred to a shingles |
| haemagglutinin | one of the influenza surface proteins detected by immunity, abrieviated to H protein |
| neuraminidase | one of the influenza surface proteins detected by immunity, abrievated to N protein |
Combine with other sets
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