6 Written Questions

1. found as a monoglutamate (not the active form)
2. the release of large immature electrolytes in the circulation, to to folate deficency (also B12 deficency)
3. before folate in foods can be absorbed POLYGLUTAMATE forms must be hydrolyzed to MONOGLUTAMATE forms
4. the reduced form of folic acid found naturally in foods and tissues
5. DIETARY FOLATE EQUIVALENTS ***DFE = 1ug of FOOD folate; supplement w/ food = 0.6ug of folate; supplement w/o food = 0.5ug of folate
6. is in polyglutamate form (pteroylpolyglutamate)

6 Multiple Choice Questions

1. conversion that needs: B12 DEPENDENT "METHIONINE SYNTHATASE"
   1. Methionine synthatase
   2. metabolically active folate
   3. N5 methyl THF mono glutamate --> polyglutamate
   4. N5 methyl THF
2. N5,N10 methylene THF for synthesis of SERINE <----------------------------> GLYCINE
   1. Function: Single C unit transfer
   2. Functions: Regeneration
   3. Functions: Amino Acid Metabolism
   4. Folate in the Blood
3. the oxidized form of the vitamin found in fortified foods and supplements
   1. Folate
   2. Folate RDA
   3. Folic acid
   4. Folate and B12
4. METHIONINE from HOMOCYSTEINE involves folate as N5 methyl THF and Vit. B12 as coenzymes (methyl cobalamin)
   1. Methionine synthatase
   2. Functions: Regeneration
   3. Folic acid
   4. Folate RDA
5. needed during periods of rapid growth or cell division; (homocysteine -----> methionine) linked to elevated blood homocysteine concentration and premature CVD
   1. Folate
   2. Folate and B12
   3. Folate RDA
   4. Folic acid
6. most common (methylated) folate found in portal circulation
   1. THF
   2. Folate
   3. N5 methyl THF
   4. Folate RDA

5 True/False Questions

1. Methionine synthatase → needed during periods of rapid growth or cell division; (homocysteine -----> methionine) linked to elevated blood homocysteine concentration and premature CVD

   True        False

2. Folate RDA → the reduced form of folic acid found naturally in foods and tissues

   True        False

3. Supplements of Folic Acid → folic acid in oxidized form = MONOGLUTATMATE and is almost completely absorbed (on an empty stomach)

   True        False

4. THF → TETRAHYDROFOLATE FORM (within intestinal cells folate is reduced to this form)

   True        False

5. Function: Single C unit transfer → METHIONINE from HOMOCYSTEINE involves folate as N5 methyl THF and Vit. B12 as coenzymes (methyl cobalamin)

   True        False