| Term | Definition |
| 1492 | Columbus Sets sail to Caribbean |
| 1519 | Hernan Cortes conquers Aztecs |
| 1532 | Francisco Pizarro conquers Incas |
| 1587 | Walter raleigh founds Roanoke |
| 1607 | Jamestown is founded |
| 1608 | Samuel Champlain founds Quebec |
| 1619 | House of Burgesses is formed |
| 1619 | John Rolfe brings tobacco to Virginia |
| 1620 | Pilgrims found Plymouth |
| 1629 | Puritans found Massachusetts |
| 1642 | English civil war begins |
| 1660 | Navigation Acts |
| 1664 | Duke of York takes over New Netherlands |
| 1675 | King Phillip's War |
| 1676 | Bacon's Rebellion |
| 1680 | Pueblo Revolt |
| 1688 | Dominion of New England |
| 1689 | Glorious Revolution |
| 1739 | First Great Awakening |
| 1739 | Stono Rebellion |
| 1741 | New York Rebellion |
| 1754 | French and Indian War Beins |
| 1760 | Peace of Paris |
| 1763 | Proclamation Line |
| 1764 | Sugar Act |
| 1766 | Townshend Revenue Act |
| 1769 | Boston Massacre |
| 1774 | First Continental Congress |
| 1774 | Intolerable Acts |
| 1775 | Battle of Lexington & Concord |
| 1775 | Second Continental Congress |
| 1776 | Declaration of Independence |
| 1777 | Battle of Saratoga |
| 1781 | Articles of Confederation |
| 1781 | Battle of Yorktown |
| 1786 | Shays' rebellion |
| 1787 | Northwest Ordinence |
| 1789 | Constitution Ratified |
| 1789 | George Washington assumes Presidency |
| 1789 | Judiciary Act |
| 1794 | Treaty of Greenville |
| 1794 | Whiskey Rebellion |
| 1795 | Jay's treaty |
| 1795 | Pinckney's Treaty |
| 1797 | John Adams assumes presidency |
| 1798 | Alien and Sedition Acts |
| 1798 | Quasi War |
| 1798 | Virginia and Kentucky Resolutions |
| 1798 | XYZ Affair |
| 1801 | John Marshall appointed chief Justice |
| 1801 | Thomas Jefferson assumes presidency |
| 1803 | Louisiana Purchase |
| 1803 | Marbury v. Madison |
| 1807 | Embargo Act |
| 1807 | Robert Fulton Launches steam boat |
| 1807 | Sinking of the Chesapeake |
| 1809 | James Madison assumes Presidency |
| 1809 | Non-intercourse Act |
| 1811 | Macon's Bill #2 |
| 1811 | War Hawks gain congressional majority |
| 1812 | War of 1812 |
| 1814 | Napoleon is defeated |
| 1814 | Treaty of Ghent |
| 1815 | Battle of New Orleans |
| 1815 | Hartford Convention ends First Party System |
| 1816 | American System |
| 1817 | James Monroe assumes Presidency |
| 1819 | McColloch v. Maryland |
| 1819 | Panic of 1819 |
| 1820 | Missouri Compromise |
| 1823 | Monroe Doctrine |
| 1824 | Gibbons v. Ogden |
| 1825 | John Quincy Adams assumes Presidency |
| 1828 | Tariff of abominations |
| 1829 | Andrew Jackson assumes Presidency |
| 1830 | Indian Removal Act |
| 1831 | Cherokee Nation v. Georgia |
| 1832 | Worcester v. Georgia |
| 1831 | Nat Turner Rebellion |
| 1833 | Compromise of 1833 |
| 1837 | Martin Van Buren assumes Presidency |
| 1837 | Panic of 1837 |
| 1841 | John Tyler assumes Presidency |
| 1841 | William Henry Harrison assumes Presidency |
| 1844 | United States annexes Texas |
| 1845 | James K Polk assumes Presidency |
| 1846 | Oregon treay |
| 1846 | Wilmot Proviso introduced |
| 1846 | Mexican American War begins |
| 1848 | Treaty of Guadalupe Hidalgo |
| 1849 | Zachary Taylor assumes Presidency |
| 1850 | Compromise of 1850 |
| 1851 | Millard Filmore assumes Presidency |
| 1852 | Uncle Tom's Cabin |
| 1853 | Franklin Pierce assumes Presidency |
| 1854 | Kansas-Nebraska Act |
| 1855 | Bleeding Kansas |
| 1857 | Dred Scott v. Sanford |
| 1857 | James Buchanan assumes Presidency |
| 1858 | Lincoln Douglas debates |
| 1859 | Raid on Harper's Ferry |
| 1860 | South Carolina secedes |
| 1861 | Abraham Lincoln assumes Presidency |
| 1861 | Fort Sumter |
| 1862 | Homestead Act |
| 1863 | Battle of Gettysburg |
| 1865 | Andrew Johnson assumes Presidency |
| 1866 | Radical Republicans achieve Veto-Proof majority |
| 1867 | Johnson impeached |
| 1867 | Reconstruction Act |
| 1869 | Knights of Labor Founded |
| 1869 | Ulysses S. Grant assumes Presidency |
| 1870 | Remaining Southern States enter the union |
| 1871 | KKK Act |
| 1876 | Battle of Little Big Horn |
| 1876 | Transcontinental Railroad completed |
| 1877 | Rutherford B. Hayes assumes Presidency |
| 1881 | Chester Arthur assumes Presidency |
| 1883 | Pendleton Act |
| 1885 | Grover Cleveland assumes Presidency |
| 1886 | American Federation of Labor founded |
| 1886 | Haymarket Square Riot |
| 1887 | Dawes Severalty Act |
| 1889 | Benjamin Harrison assumes Presidency |
| 1890 | Battle of Wounded Knee |
| 1890 | Sherman anti-trust act |
| 1892 | Homestead Strike |
| 1893 | Panic of 1893 |
| 1893 | The Significance of the Frontier in American History |
| 1894 | Pullman Strike |
| 1896 | Plessy v. Ferguson |
| 1897 | William McKinley assumes Presidency |
| 1898 | Maine Explodes off of Cuba |
| 1898 | Spanish American War |
| 1899 | Filipino War |
| 1901 | Theodore Roosevelt assumes Presidency |
| 1909 | William Howard Taft assumes Presidency |
| 1910 | NAACP founded |
| 1914 | WWI Begins |
| 1915 | Sinking of Lusitania |
| 1917 | Congress Declares War on Germany (WWI) |
| 1919 | Prohibition passed |
| 1919 | Versailles peace conference |
| 1920 | Women's suffrage |
| 1921 | Warren G Harding assumes Presidency |
| 1922 | Washington Naval Conference |
| 1923 | Calvin Coolidge assumes Presidency |
| 1924 | Dawes-Young Plan |
| 1925 | Scopes-Monkey trial |
| 1929 | Herbert Hoover assumes Presidency |
| 1929 | Stock Market Crash |
| 1933 | First New Deal |
| 1933 | FDR assumes Presidency |
| 1935 | 1st Neutrality Act |
| 1935 | Second New Deal |
| 1936 | 2nd Neutrality Act |
| 1937 | 3rd Neutrality Act |
| 1941 | Pearl Harbor |
| 1945 | American Forces Reach Japan |
| 1945 | Atomic bomb dropped |
| 1945 | Harry truman assumes Presidency |
| 1947 | National Security Act |
| 1947 | Taft-Hartley Act |
| 1948 | Berlin Airlift |
| 1950 | Korean War Begins |
| 1953 | 38th Parallel Armistice |
| 1953 | Dwight D. Eisenhower Assumes Presidency |
| 1954 | Brown v. Board of Education |
| 1955 | Montgomery Bus Boycott |
| 1956 | Highway Act |
| 1957 | Little Rock Nine |
| 1959 | Communist Revolution in Cuba |
| 1961 | Bay of Pigs |
| 1962 | Cuban missile crisis |
| 1963 | Birmingham riot |
| 1963 | March on Washington |
| 1964 | Lyndon B. Johnson Assumes Presidency |
| 1964 | Civil Rights Act |
| 1965 | Voting Rights Act |
| 1954 | Geneva Convention |
| 1965 | Johnson sends troops to Vietnam |
| 1968 | Tet Offensive |
| 1973 | Paris Peace Accords |
| 1975 | North Vietnam reinvades South Vietnam |
| 1969 | Richard Nixon assumes Presidency |
| 1972 | SALT |
| 1970 | Clean Air Act |
| 1974 | Nixon Resigns |