| Term | Definition |
|---|
| phenylalanine hydroxylase | phenylalanine --> tyrosine **req's tetrahydrobiopterin (THB) |
| tyrosine hydroxylase | tryosine --> DOPA **req's THB |
| DOPA decarboxylase | DOPA --> dopamine **req's PLP |
| dopamine ?-hydroxylase | dopamine --> NE **req's Vit. C |
| phenylethanolamine N methyl transferase | NE --> Epi **req's SAM |
| monoamine oxidase (MAO) + COMT | NE and/or Epi --> vanillyl mandelic acid (VMA) --> excreted in urine |
| tryptophan hydroxylase | tryptophan --> 5-hydroxy tryptophan **req's THB |
| a.a. decarboxylase | 5-hydroxy tryptophan --> 5-hydroxy tryptamine (serotonin) **bifunctional enz |
| a.a. decarboxylase | histidine --> histamine **bifunctional enz *histamine --> vasodilator produced during allergic rxns effects of histamine are blocked by antihistamine drugs |
| glutamate decarboxylase | glutamic acid --> GABA (gaba amino butyric acid) **req's PLP |
| nitric oxide synthase | arginine --> nitric oxide + ornithine *NO --> local vasodilation of coronary bl vessels & incr bl Q |
| creatine kinase/creatine phosphkinase (CK/CPK) | creatine <--> creatine - P |
| DHB reductase | DHB --> THB |
| Parkinson's disease | "loss of dopamine producing cells Sx: movement disorders: spasticity, tremors, postural instability, loss of memory" |
| Pheochromocytoma | "tumor of adrenal gland --> overproduction of catecholamines (Epi and NE) Sx: hypertension, tachycardia, headache, sweating" |
| carcinoid syndrome | neuroendocrine gland tumor --> incr production of serotonin (5-HT) Sx: cutaneous flushing, sweating, diarrhea, bronchospasm, incr [5-HIAA] in urine |
| Albinism | "deficiency of tyrosinase --> decr or absent melanin Sx: decr visual acquity, little to no skin pigmentation --> photosensitivity --> incr risk of skin CA" |
Combine with other sets
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